1 0 0 0 OA Studies on Penam Sulfones
- 著者
- EDUARDO L. SETTI NARENDER A. V. REDDY OLUDOTUN A. PHILLIPS DAVID P. CZAJKOWSKI KEVIN ATCHISON HARNINDER ATWAL RONALD G. MICETICH SAMARENDRA N. MAITI CHIEKO KUNUGITA AKIO HYODO
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.49, no.9, pp.944-946, 1996-09-25 (Released:2006-11-21)
- 参考文献数
- 6
- 被引用文献数
- 4 5
1 0 0 0 OA Chemical Modification of Tazobactam
- 著者
- EDUARDO L. SETTI CHARLES FIAKPUI OLUDOTUN A. PHILLIPS DAVID P. CZAJKOWSKI KEVIN ATCHISON RONALD G. MICETICH SAMARENDRA N. MAITI CHIEKO KUNUGITA AKIO HYODO
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.48, no.11, pp.1320-1329, 1995-11-25 (Released:2006-04-19)
- 参考文献数
- 19
- 被引用文献数
- 3 6
A series of 2β-[(4-substituted)-l, 2, 3-triazol-l-yl]methyl penicillanic acid sulfones was synthesized as β-lactamase inhibitors. Many of these compounds showed good in vitro inhibitory activity against penicillinase, cefotaximase and plasmid-mediated class III TEM enzymes, but exhibited weaker cephalosporinase inhibition. One member in this series-2β-[(4-pyridiniummethyl)-l, 2, 3-triazol-lyl]methyl-6, 6-dihydropenicillanate 1, 1-dioxide (12a), when tested in combination with piperacillin, showed excellent synergistic activity against microorganisms producing plasmid-mediated enzymes, but had insufficient activity against microorganisms producing chromosomally mediated class I enzymes.
- 著者
- CHAEUK IM SAMARENDRA N. MAITI RONALD G. MICETICH MOHSEN DANESHXALAB KEVIN ATCHISON OLUDOTUN A. PHILLIPS CHIEKO KUNUGITA
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.47, no.9, pp.1030-1040, 1994-09-25 (Released:2006-04-19)
- 参考文献数
- 15
- 被引用文献数
- 31 42
The synthesis of β-lactamase inhibitory activity of a series of sodium 6-[(1-heteroarylthioethyl-1, 2, 3-triazol-4-yl)methylene]pemcillanate 1, 1-dioxides are described. Their activity was compared with tazobactam and sulbactam. The Z-isomers were more active than the E-isomers. The in vitro activity of the Z-isomers of the phenylthiadiazole derivatives (13a and 15a) was better than sulbactam against the tested β-lactamases and comparable to tazobactam especially against TEM-2 and cephalosporinase. But their synergistic activity with five antibiotics was inferior to tazobactam.