- 著者
- Chihiro Tsukano Satoshi Suetsugu Nobusuke Muto Yoshiji Takemoto
- 出版者
- The Pharmaceutical Society of Japan
- 雑誌
- Chemical and Pharmaceutical Bulletin (ISSN:00092363)
- 巻号頁・発行日
- vol.65, no.12, pp.1167-1174, 2017-12-01 (Released:2017-12-01)
- 参考文献数
- 43
Tetrahydrobiphenylene consists of cyclobutene fused with benzene and cyclohexene rings. In this paper, a direct method for synthesizing tetrahydrobiphenylenes based on a palladium (Pd)(0)-catalyzed C(sp2)–H functionalization was investigated. The developed method was applied to the synthesis of several tetrahydrobiphenylenes having an oxygen functionality at the ring juncture. The derivatization of a tetrahydrobiphenylene is also reported.
2 0 0 0 Synthesis of 2-Iminoindolines via Samarium Diiodide Mediated Reductive Cyclization of Carbodiimides
- 著者
- Takayuki Ishida Chihiro Tsukano Yoshiji Takemoto
- 出版者
- (社)日本化学会
- 雑誌
- Chemistry Letters (ISSN:03667022)
- 巻号頁・発行日
- vol.41, no.1, pp.44-46, 2012-01-05 (Released:2011-12-24)
- 参考文献数
- 43
- 被引用文献数
- 16
A method of synthesizing 2-iminoindolines using samarium diiodide (SmI2) is reported. In the presence of tert-butyl alcohol, treatment of carbodiimides bearing α,β-unsaturated carbonyl moieties with a stoichiometric amount of SmI2 afforded 2-iminoindolines in moderate to high yields. The products were isolated after Boc protection of the amidine moieties. This reaction proved to be applicable to lactams and acyclic/cyclic esters as substrates.