著者

Masaru Yamasaki Takayuki Ishida

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

vol.44, no.7, pp.920-921, 2015-07-05 (Released:2015-07-05)

参考文献数

25

被引用文献数

21

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A novel dinuclear iron(II) complex [{Fe(py3COH)(NCS)(μ-NCS)}2](PrOH)2 was prepared. Each Fe ion is coordinated with three N atoms from tridentate tris(2-pyridyl)methanol (py3COH) and two N and one S atoms from NCS− coligand. It showed a one-step gradual spin-crossover at T1/2 = 207 K. This compound is the first spin-crossover material having an FeN5S coordination structure.

著者

Takayuki Ishida Satoko Naoe Masanori Nakakuki Hiroyuki Kawano Kazunori Imada

出版者

一般社団法人 日本動脈硬化学会

雑誌

Journal of Atherosclerosis and Thrombosis (ISSN:13403478)

巻号頁・発行日

pp.28167, (Released:2015-05-27)

参考文献数

34

被引用文献数

1 21

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Aim: Vascular endothelial dysfunction is considered an early predictor of atherosclerosis. It has been proven that elevated blood levels of free fatty acids pose a substantial risk for the development of cardiovascular disease. In this study, we examined the effects of palmitic acid (PA), a saturated fatty acid, on endothelial function by using the expression of adhesion molecule, cytokines, and inflammatory protein as indicators, as well as investigated the effects of eicosapentaenoic acid, an n-3 polyunsaturated fatty acid.Methods: Human umbilical vein endothelial cells (HUVEC) were exposed to PA and EPA.Results: When HUVEC were exposed to PA, there was an increase in the expression of adhesion molecule, cytokines, and inflammatory protein (ICAM-1, MCP-1, interleukin-6, PTX3). PA augmented the expression of long-chain acyl-CoA synthetase (ACSL) and the cyclin-dependent kinase inhibitor p21, and enhanced the phosphorylation of p65, a component of NF-κB. ACSL inhibition and siRNA-mediated ACSL3 knockdown suppressed the PA-induced increase in the expression of adhesion molecule, cytokines, and inflammatory protein, and ACSL inhibition suppressed the enhancement of p65 phosphorylation. In addition, p21 knockdown suppressed the PA-induced increase in the expression of MCP-1 and ICAM-1. EPA suppressed the PA-induced increase in the expression of ACSL and p21, the enhancement of p65 phosphorylation, as well as the associated increase in the expression of ICAM-1, MCP-1, interleukin-6, and PTX3.Conclusions: These results suggest that the ACSL, p21, and NF-κB-dependent pathway may possibly be involved in PA-induced vascular endothelial dysfunction, and that EPA ameliorates this at least in part through the regulation of ACSL3 expression.

著者

Takayuki Ishida Chihiro Tsukano Yoshiji Takemoto

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

vol.41, no.1, pp.44-46, 2012-01-05 (Released:2011-12-24)

参考文献数

43

被引用文献数

16

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A method of synthesizing 2-iminoindolines using samarium diiodide (SmI2) is reported. In the presence of tert-butyl alcohol, treatment of carbodiimides bearing α,β-unsaturated carbonyl moieties with a stoichiometric amount of SmI2 afforded 2-iminoindolines in moderate to high yields. The products were isolated after Boc protection of the amidine moieties. This reaction proved to be applicable to lactams and acyclic/cyclic esters as substrates.