著者

Erika Hishida Yuko Ono Kazuho Oe Toshimi Imai Hiromichi Yoshizawa Takeo Nakaya Hirotoshi Kawata Tetsu Akimoto Osamu Saito Daisuke Nagata

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.62, no.16, pp.2381-2387, 2023-08-15 (Released:2023-08-15)

参考文献数

47

被引用文献数

2

---

We herein report a case of acute kidney injury (AKI) presenting as acute interstitial nephritis (AIN) after the first dose of the BNT162b2 mRNA vaccine against coronavirus disease 2019 (COVID-19). A 69-year-old man with a history of diabetes and hypertension presented with AKI 4 days after receiving the vaccine. Despite the administration of methylprednisolone pulse treatment, his renal function worsened, which prompted us to initiate temporal hemodialysis. His renal function subsequently improved, and a renal biopsy confirmed AIN and glomerular capillary IgA deposition without apparent crescents. The clinical history and histological findings suggest a relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and AIN as a rare side effect.

著者

Takahiro Shinzato Ken Ohara Hiroaki Kaminaga Taro Sugase Takahiro Masuda Daisuke Nagata Katano Saki Yoshitaka Kinoshita Taro Kubo Toshihiro Shimizu Koji Nanmoku Takashi Yagisawa

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.59, no.21, pp.2733-2736, 2020-11-01 (Released:2020-11-01)

参考文献数

15

被引用文献数

1

---

A transdermal patch formulation of a non-steroidal anti-inflammatory drug (NSAID) used by a 44-year-old man resulted in acute interstitial nephritis and acute tubular injury. This patient also had a history of mild kidney dysfunction and osteoporosis. The NSAID patch had been prescribed after a traffic accident. He was also receiving a vitamin D analog and taking over-the-counter calcium supplements. Two months later, renal dysfunction and hypercalcemia were discovered. A renal biopsy showed acute interstitial nephritis and acute tubular injury. Once these agents were withdrawn, the renal function recovered. This is the first reported occurrence of biopsy-proven acute interstitial nephritis attributable to NSAID patch usage.