A transdermal patch formulation of a non-steroidal anti-inflammatory drug (NSAID) used by a 44-year-old man resulted in acute interstitial nephritis and acute tubular injury. This patient also had a history of mild kidney dysfunction and osteoporosis. The NSAID patch had been prescribed after a traffic accident. He was also receiving a vitamin D analog and taking over-the-counter calcium supplements. Two months later, renal dysfunction and hypercalcemia were discovered. A renal biopsy showed acute interstitial nephritis and acute tubular injury. Once these agents were withdrawn, the renal function recovered. This is the first reported occurrence of biopsy-proven acute interstitial nephritis attributable to NSAID patch usage.
44歳男性の交通事故後の国内症例報告
エルデカルシトールと市販カルシウムサプリメント併用による高Ca血症の影響もあるのかなあ
【Intern Med 59(21) p2733-2736, 2020】
Acute Interstitial Nephritis and Acute Tubular Injury Due to a Transdermal Loxoprofen Patch
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