著者

Takahiro Shinzato Ken Ohara Hiroaki Kaminaga Taro Sugase Takahiro Masuda Daisuke Nagata Katano Saki Yoshitaka Kinoshita Taro Kubo Toshihiro Shimizu Koji Nanmoku Takashi Yagisawa

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.59, no.21, pp.2733-2736, 2020-11-01 (Released:2020-11-01)

参考文献数

15

被引用文献数

1

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A transdermal patch formulation of a non-steroidal anti-inflammatory drug (NSAID) used by a 44-year-old man resulted in acute interstitial nephritis and acute tubular injury. This patient also had a history of mild kidney dysfunction and osteoporosis. The NSAID patch had been prescribed after a traffic accident. He was also receiving a vitamin D analog and taking over-the-counter calcium supplements. Two months later, renal dysfunction and hypercalcemia were discovered. A renal biopsy showed acute interstitial nephritis and acute tubular injury. Once these agents were withdrawn, the renal function recovered. This is the first reported occurrence of biopsy-proven acute interstitial nephritis attributable to NSAID patch usage.