著者

Nobuhiro FUJITA Akihiro NISHIE Yoshiki ASAYAMA Kousei ISHIGAMI Yasuhiro USHIJIMA Yukihisa TAKAYAMA Daisuke OKAMOTO Koichiro MORITA Ken SHIRABE Kazuhiro KOTO Yuichiro KUBO Yoshinao ODA Hiroshi HONDA

出版者

Japanese Society for Magnetic Resonance in Medicine

雑誌

Magnetic Resonance in Medical Sciences (ISSN:13473182)

巻号頁・発行日

vol.15, no.1, pp.111-120, 2016-01-01 (Released:2016-01-12)

参考文献数

28

被引用文献数

7 9

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Purpose: We attempted to clarify the relationship between the signal intensity (SI) in the hepatobiliary phase of gadoxetic acid-enhanced magnetic resonance (MR) imaging and the efficacy of hepatic arterial infusion chemotherapy (HAIC) in hepatocellular carcinomas (HCCs).Methods: We enrolled 14 patients with HCCs who underwent gadoxetic acid-enhanced MR imaging prior to HAIC using cisplatin and 5-fluorouracil. In the hepatobiliary phase, we calculated the SI of the HCCs and the background liver. In cases with multiple HCCs, we calculated the SI of the largest lesion. Patients were classified into high (n = 7) and low intensity (n = 7) groups based on the median value of the SI ratio (SI of the tumor/SI of the background liver). We analyzed progression-free survival using the Kaplan-Meier method and the log-rank test. In the 5 patients with a history of HCC surgery, we compared the expression of immunohistochemical organic anion-transporting polypeptide (OATP) 8 between the high and low intensity groups by chi-square test.Results: The SI ratios were 0.568 ± 0.093 (mean ± standard deviation) in the high intensity group and 0.251 ± 0.086 in the low intensity group. Compared to the group with low signal intensity, the group with high signal intensity demonstrated significantly lower serum levels of alpha fetoprotein (AFP) (P = 0.0350), significantly higher progression-free survival (P = 0.0108), better differentiation of tumor grade at histologic examination (P = 0.0253), and significantly higher OATP8 expression (P = 0.0253).Conclusion: Patients with HCCs of high SI ratio in the hepatobiliary phase of gadoxetic acid-enhanced MR imaging can respond better to HAIC.

著者

Koichi Takemura Daisuke Ohshima Akihiro Noriki Daisuke Okamoto Akio Ukita Jun Ushida Masatoshi Tokushima Takanori Shimizu Ichiro Ogura Daisuke Shimura Tsuyoshi Aoki Takeru Amano Takahiro Nakamura

出版者

The Japan Institute of Electronics Packaging

雑誌

Transactions of The Japan Institute of Electronics Packaging (ISSN:18833365)

巻号頁・発行日

vol.15, pp.E21-012-1-E21-012-13, 2022 (Released:2022-04-25)

参考文献数

25

被引用文献数

5

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We propose silicon (Si)-photonics-embedded interposers as a novel packaging platform to achieve co-packaged optics. An interposer is an organic substrate that has Si-photonics transceiver dies buried in it and polymer optical waveguides connecting the embedded Si chips and optical connectors. We also developed a Si-photonics-device-embedding process and investigated the properties and operations of embedded Si-photonics devices as a feasibility study. The embedded arrayed waveguide grating and reflective optical filter showed a wavelength shift on the order of 0.1 nm with our embedding process. The shifts seem to be due to the difference in ambient temperature during the measurements and induced strain. Though this embedding process is presumed to affect the spectrum for Si-photonics devices, the difference is small enough to be controlled. Embedded Si-photonics transmitter- and receiver-integrated circuits successfully demonstrated 25-Gb/s operations. The proposed Si-photonics-embedded interposer is a promising candidate for a co-packaged optics platform to eliminate the interconnect bandwidth bottleneck for high-performance computing systems.

著者

Yukihisa Takayama Akihiro Nishie Daisuke Okamoto Nobuhiro Fujita Yoshiki Asayama Yasuhiro Ushijima Tomoharu Yoshizumi Masami Yoneyama Kousei Ishigami

出版者

Japanese Society for Magnetic Resonance in Medicine

雑誌

Magnetic Resonance in Medical Sciences (ISSN:13473182)

巻号頁・発行日

pp.mp.2020-0151, (Released:2021-04-20)

参考文献数

33

被引用文献数

5

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Purpose: To evaluate the utility of T2-enhanced spin-echo imaging using the time-reversed gradient echo sequence (T2FFE imaging) in the hepatobiliary phase (HBP) of gadoxetic acid-enhanced MRI (Gd-EOB-MRI) for differentiating hemangiomas from metastatic tumors.Methods: A total of 61 patients with 133 liver lesions, including 37 hemangiomas and 96 metastatic tumors, were scanned by Gd-EOB-MRI. Four data sets were independently analyzed by two readers: (1) 3D fat-suppressed T2-weighted imaging (FS-T2WI) alone; (2) the combination of 3D FS-T2WI and T2FFE imaging in the HBP of Gd-EOB-MRI; (3) the combination of 3D FS-T2WI, diffusion-weighted imaging (DWI) with the b-value of 1000 s/mm2 and the apparent diffusion coefficient (ADC); and (4) a dynamic study of Gd-EOB-MRI. After classifying the lesion sizes as ≤ 10 mm or > 10 mm, we conducted a receiver-operating characteristic analysis to compare diagnostic accuracies among the four data sets for differentiating hemangiomas from metastatic tumors.Results: The areas under the curves (AUCs) of the four data sets of two readers were: (1) ≤ 10 mm (0.85 and 0.91) and > 10 mm (0.88 and 0.97), (2) ≤ 10 mm (0.94 and 0.94) and > 10 mm (0.96 and 0.95), (3) ≤ 10 mm (0.90 and 0.87) and > 10 mm (0.89 and 0.95), and (4) ≤ 10 mm (0.62 and 0.67) and > 10 mm (0.76 and 0.71), respectively. Data sets (2) and (3) showed no significant differences in AUCs, but both showed significantly higher AUCs compared to that of (4) regardless of the lesion size (P < 0.05).Conclusion: The combination of 3D FS-T2WI and T2FFE imaging in the HBP of Gd-EOB-MRI achieved an accuracy equivalent to that of the combination of 3D FS-T2WI, DWI, and ADC and might be helpful in differentiating hemangiomas from metastatic tumors.