- 著者
- Sobi Asako Laurean Ilies Pritha Verma Saki Ichikawa Eiichi Nakamura
- 出版者
- (社)日本化学会
- 雑誌
- Chemistry Letters (ISSN:03667022)
- 巻号頁・発行日
- pp.131205, (Released:2014-02-04)
- 被引用文献数
- 3
A theoretical study on a tripodal alkoxydipshophine ligand (POP), which accelerates the nickel-catalyzed monosubstitution of a polyfluoroarene with an organozinc reagent, revealed that the alkoxy group and the diphosphine act independently to facilitate cooperation of a Lewis acid and a transition metal.
- 著者
- Daisuke Sueta Koichi Kaikita Nobukazu Okamoto Soichiro Yamabe Masanobu Ishii Yuichiro Arima Miwa Ito Yu Oimatsu Tatsuro Mitsuse Satomi Iwashita Eiichi Nakamura Seiji Hokimoto Hiroshi Mizuta Hisao Ogawa Kenichi Tsujita for the ESCORT-TKA Study Investigators
- 出版者
- 日本循環器学会
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- pp.CJ-17-0612, (Released:2017-09-16)
- 参考文献数
- 50
- 被引用文献数
- 4
Background:The pharmacological advantage of combining physiotherapy with anticoagulants for the prevention of venous thromboembolism (VTE) after total knee arthroplasty (TKA) is not fully known. Herein we investigated the potential benefit of this combination therapy in patients undergoing TKA.Methods and Results:The 38 patients were randomly assigned to a physiotherapy group (n=19) or a physiotherapy plus 30 mg/day edoxaban group (n=19). The occurrence of VTE was evaluated, as were serial changes in parameters measured by the Total Thrombus-formation Analysis System, a novel system for quantitatively analyzing thrombus formation using microchips with thrombogenic surfaces (collagen plus tissue factor, atheroma [AR]-chip). Combination therapy significantly reduced the incidence of VTE after TKA compared with monotherapy (P=0.038). The area under the curve (AUC) of thrombus formation for the AR-chip (AR10-AUC30) was significantly lower in the combination group (P=0.001) on Day 7 after TKA than before TKA, but no significant change was observed with monotherapy (P=0.809). In 13 VTE-positive patients, AR10-AUC30was significantly lower in the combination group (n=3) than in the monotherapy group (n=10) on Day 7 (P=0.045).Conclusions:The combination of physiotherapy and edoxaban significantly reduced the incidence of VTE after TKA compared with physiotherapy alone. However, it is possible that VTE occurrence after TKA is not only associated with thrombogenicity, but also rheological factors.
- 著者
- Hayato Tsuji Guillaume Marcel Olivier Favier Chikahiko Mitsui Sunri Lee Daisuke Hashizume Eiichi Nakamura
- 出版者
- (社)日本化学会
- 雑誌
- Chemistry Letters (ISSN:03667022)
- 巻号頁・発行日
- vol.40, no.6, pp.576-578, 2011-06-05 (Released:2011-04-28)
- 参考文献数
- 38
- 被引用文献数
- 23
2,6-Di(2-pyridyl)benzo[1,2-b:4,5-b′]difuran (2-PyBDF) shows a π–π-stacking packing structure in a single crystal and some intriguing properties: mechanochromism in the solid state, and solvent and concentration dependence of absorption and emission spectra.