- 著者
- Elnaz NAKHAEI Ko TAKEHARA Hikari SATO Khadijah ZAI Akihiro KISHIMURA Takeshi MORI Yoshiki KATAYAMA
- 出版者
- The Japan Society for Analytical Chemistry
- 雑誌
- Analytical Sciences (ISSN:09106340)
- 巻号頁・発行日
- vol.34, no.4, pp.501-504, 2018-04-10 (Released:2018-04-10)
- 参考文献数
- 23
- 被引用文献数
- 2 5
Therapeutic peptides and diagnostic agents with their molecular size below the renal clearance threshold suffer from short blood circulation time. Here, we report a novel design of peptide-based ligand with a strong binding affinity to human serum albumin (HSA), which can be used as a tag to extend the blood circulation of small-size molecules. We designed ligands with dual alkyl groups connected with a negatively charged spacer. The ligands showed both higher binding affinity to HSA and a higher retention in mice blood than that of a single alkylated peptide.