著者
KOKO SUGAWARA MASAMI HATORI YUJI NISHIYAMA KOJI TOMITA HIDEO KAMEI MASATAKA KONISHI TOSHIKAZU OKI
出版者
JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
雑誌
The Journal of Antibiotics (ISSN:00218820)
巻号頁・発行日
vol.43, no.1, pp.8-18, 1990-01-25 (Released:2006-04-19)
参考文献数
3
被引用文献数
54 65

Streptomyces hygroscopicus No. P247-71 (ATCC 53709) produced a novel antibiotic eponemycin which exhibited specific in vivo antitumor effect against B16 melanoma. Structural studies assigned (4S)-1, 2-epoxy-2-hydroxymethyl-4-(N-isooctanoyl-L-serylamino)-6-methylhept-6-ene-3-one to eponemycin which is unrelated to the known antitumor antibiotics.