著者

SHOICHIRO OZAKI TOSHIO NAGASE HIROFUMI TAMAI HARUKI MORI AKIO HOSHI MASAAKI IIGO

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.35, no.9, pp.3894-3897, 1987-09-25 (Released:2009-10-19)

参考文献数

11

被引用文献数

8 9

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For the purpose of diminishing the toxicity of 5-fluorouracil (1) and obtaining biologically active derivatives of 1 suitable for oral administration, alkylthiomethyl, alkylsulfinylmethyl, alkylsulfonylmethyl, and acylthiomethyl groups were introduced at the 1- and 3-positions of 1. The antitumor activity of these synthetic compounds was tested against L1210 leukemia in mice. 1-Alkylthiomethyl-5-fluorouracils showed weak antitumor activity at a high dose (300 mg/kg).

著者

Katsuhiko SANDO Takeshi YAMAMOTO Kenji SAWADA Tomoyuki TANIGUCHI Nobuyuki SOWA Haruki MORI Takahiro KONDO

出版者

The Japan Society of Mechanical Engineers

雑誌

Mechanical Engineering Journal (ISSN:21879745)

巻号頁・発行日

pp.20-00497, (Released:2021-03-03)

参考文献数

11

被引用文献数

1

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This paper describes a design method of a friction reducer device using a loading cam to suppress unstable vibration. Nonlinear simulation and energy analysis of numerical solutions demonstrates that destabilization is caused by the large phase difference between the slipping velocity in the translation direction and that in the rotation direction. It was found that similarly unstable vibration occurs in various structures using wedge rollers with translational and rotational motion. The analytical equation could be simplified by focusing on the motion factor that affects the slip velocity of the power transmission surface, which is the factor of vibration. Consequently, the design method for suppressing vibration could be expressed by a mathematical formula. This equation is validated by using the results of experiments conducted in the previous work of the current authors. Furthermore, from this equation, we proposed that vibration could be suppressed by the parameter balance of the power transmission device without using damping. The power transmission surface slips when a quick torque is input and damping is used. The proposed design can handle a quick torque response and reduce the weight of the reducer. Specifically, the shape of the wedge roller is made lighter, so that the moment of inertia of the roller is not lowered, or the wedge roller is set as a small roller.

著者

Hiroyuki Shimogawa Haruki Mori Atsushi Wakamiya Yasujiro Murata

出版者

(社)日本化学会

雑誌

Chemistry Letters (ISSN:03667022)

巻号頁・発行日

pp.130360, (Released:2013-06-01)

被引用文献数

19

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Dibenzo[b,g]-fused and dithieno[b,g]-fused BODIPY derivatives were synthesized, and the electronic impacts of the introducing dibenzo- and dithieno-fused structures at both of the b and g bonds in the BODIPY skeleton were investigated. Electrochemical and photophysical measurements demonstrated that these structural modifications effectively enhance the electron accepting ability of the BODIPY skeleton leading to the red-shifted absorption.