- 著者
- Shinya WATANABE Jumpei ITO Takuya BABA Takahiro HIRATSUKA Kyohei KUSE Haruyo OCHI Yukari ANAI Masaharu HISASUE Hajime TSUJIMOTO Kazuo NISHIGAKI
- 出版者
- 公益社団法人 日本獣医学会
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- pp.13-0344, (Released:2013-12-09)
- 被引用文献数
- 1 3
Feline leukemia virus (FeLV) induces neoplastic and non-neoplastic diseases in cats. The transduction of cellular genes by FeLV is sometimes observed and associated with neoplastic diseases including lymphoma and sarcoma. Here, we report the first natural case of feline Notch2 transduction by FeLV in an infected cat with multicentric lymphoma and hypercalcemia. We cloned recombinant FeLVs harboring Notch2 in the env gene. Notch2 was able to activate expression of reporter gene, similar to what was previously reported in cats with experimental FeLV-induced thymic lymphoma. Our findings suggest that the transduction of Notch2 strongly correlates with FeLV-induced lymphoma.