著者

HIROKI SEIKE SHINYA WATANABE

出版者

The Anthropological Society of Nippon

雑誌

Anthropological Science (ISSN:09187960)

巻号頁・発行日

vol.129, no.2, pp.151-164, 2021 (Released:2021-09-01)

参考文献数

30

被引用文献数

1

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South American camelids, which were domesticated in the Central Andes, have been emphasized for their secondary uses (e.g. llamas as pack animals and alpacas for their wool). In modern pastoral societies the use of mature animals for meat is not efficient. However, it is interesting that cut marks have often been found on archaeological animal bones. This study aimed to describe butchering of camelids through macroscopic observation of cut marks in the Middle Horizon period, during the Wari Empire (600–1000 CE), when the use of camelids reached its peak, and to test whether these activities are consistent with ethnoarchaeological and ethnographic findings. The materials used here are camelid bones with cut marks from El Palacio in the northern highlands of Peru. They were assigned to Middle Cajamarca Phases B and C, and a part of the Late Cajamarca Phase (800–1000 CE). In this study, cut marks on animal bones were observed by macroscopy, and analyses were focused on their distribution, frequencies, and direction. Cut marks on camelid bones from El Palacio were observed over the entire body, suggesting that these marks were caused by dismembering, skinning, and extraction of meat, fat, and marrow. The frequencies of cut marks on camelid bones at El Palacio was 1.3%, lower than that in the Formative Period. This lower frequency might have been caused by more fragmented bones in the former. Furthermore, it is possible that the use of secondary products was emphasized at El Palacio. Cut marks were concentrated on the ventral side of each bone. This can be attributed to the butchering procedure described from ethnoarchaeology and ethnography, in which animal was turned on its back for dismemberment and removal of its internal organs from the ventral side, being careful not to soil the earth for ritual considerations.

著者

Shinya WATANABE Jumpei ITO Takuya BABA Takahiro HIRATSUKA Kyohei KUSE Haruyo OCHI Yukari ANAI Masaharu HISASUE Hajime TSUJIMOTO Kazuo NISHIGAKI

出版者

公益社団法人 日本獣医学会

雑誌

Journal of Veterinary Medical Science (ISSN:09167250)

巻号頁・発行日

pp.13-0344, (Released:2013-12-09)

被引用文献数

1 3

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Feline leukemia virus (FeLV) induces neoplastic and non-neoplastic diseases in cats. The transduction of cellular genes by FeLV is sometimes observed and associated with neoplastic diseases including lymphoma and sarcoma. Here, we report the first natural case of feline Notch2 transduction by FeLV in an infected cat with multicentric lymphoma and hypercalcemia. We cloned recombinant FeLVs harboring Notch2 in the env gene. Notch2 was able to activate expression of reporter gene, similar to what was previously reported in cats with experimental FeLV-induced thymic lymphoma. Our findings suggest that the transduction of Notch2 strongly correlates with FeLV-induced lymphoma.

著者

Satoru OSUKA Shingo TAKANO Shinya WATANABE Eiichi ISHIKAWA Tetsuya YAMAMOTO Akira MATSUMURA

出版者

社団法人 日本脳神経外科学会

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

vol.52, no.4, pp.186-193, 2012 (Released:2012-04-23)

参考文献数

31

被引用文献数

14 52

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Antiangiogenic strategy is promising for malignant glioma. Histone deacetylase inhibitors (HDACIs) are unique anticancer agents that exhibit antiangiogenic effects. The in vitro and in vivo antiangiogenic effects of HDACIs, valproic acid (VPA), were investigated in malignant glioma in the brain. In vitro, VPA preferentially inhibited endothelial cell proliferation compared to glioma cell proliferation at the optimum concentration in a dose-dependent manner. VPA reduced vascular endothelial growth factor (VEGF) secretion of glioma cells in a dose-dependent manner under both normoxic and hypoxic conditions. VPA was also found to inhibit tube formation in the angiogenesis assay. In vivo, treatment with VPA combined with irinotecan reduced the number of vessels expressing factor VIII in the brain tumor model. VPA inhibits glioma angiogenesis by direct (inhibition of endothelial cell proliferation and tube formation) and indirect (decreased secretion of VEGF by glioma cells) mechanisms. These data suggest a potential role for VPA as an adjuvant therapy for patients with malignant glioma.