- 著者
-
Lobna MKAOUAR
Yoshifumi ENDO
He Xi JUN
Soo-Jung LEE
Tassanee JAROENSONG
Manabu MOCHIZUKI
Kazuyuki UCHIDA
Hiroyuki NAKAYAMA
Nobuo SASAKI
Takayuki NAKAGAWA
- 出版者
- 公益社団法人 日本獣医学会
- 雑誌
- Journal of Veterinary Medical Science (ISSN:09167250)
- 巻号頁・発行日
- vol.74, no.6, pp.713-718, 2012 (Released:2012-07-04)
- 参考文献数
- 29
- 被引用文献数
-
2
5
1
In this study, the nuclear expression of nuclear factor kappa B (NF-κB) in 48 tissues specimens from 25 canine spontaneous mammary gland tumor (MGT) patients was assessed by immunohistochemistry to compare their levels with clinical features, histological types, prognostic outcomes and proliferative activities, including the mitotic index (MI) and cylcinD1 expression. Twelve of eighteen (66.7%) malignant tumor tissues showed greater than 10% nuclear staining, while benign tumor and hyperplastic tissues showed less than 10% nuclear staining. Higher nuclear expression of NF-κB was positively correlated with larger tumor size, lymph node metastasis and higher MI; however, no correlation was observed with distant metastasis and cyclin D1 expression. Higher NF-κB nuclear expression correlated with shorter patient survival. These findings suggest that NF-κB is a useful prognostic factor for canine MGT patients.