著者

Hitoshi Goto Michihisa Umetsu Daijirou Akamatsu Hirofumi Sugawara Ken Tsuchida Yoshitaro Yoshida Shunya Suzuki Takashi Kamei

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

pp.CJ-20-0713, (Released:2021-03-09)

参考文献数

28

被引用文献数

1

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Background:Because anticoagulant drugs for ambulatory patients with cancer-associated venous thromboembolism (CAT) are limited to warfarin and direct oral anticoagulants (DOACs) in Japan, it is important to assess the outcomes of both drugs.Methods and Results:We retrospectively assessed the outcomes of CAT patients who were treated with warfarin or edoxaban between 2011 and 2017. The assessment was limited to the duration of anticoagulant administration. CAT patients who did not receive anticoagulation therapy were also compared with the warfarin and edoxaban groups. We enrolled 111 CAT patients treated with warfarin (n=58, mean age 62.6 years, mean time in therapeutic range [TTR] % 61.1) or edoxaban (n=53, mean age 64.6 years). Although venous thromboembolism (VTE) recurred in 2 warfarin-treated patients, the 2 treatment groups were not significantly different (P=0.18). Bleeding during anticoagulation therapy occurred in 6 warfarin-treated patients (2 with major bleeding) and in 5 edoxaban-treated patients (no major bleeding) (P=1.0). The non-anticoagulation group (n=37) showed a high recurrence rate (P<0.01) compared with the anticoagulant group.Conclusions:This study showed that warfarin and edoxaban are equally effective in preventing VTE recurrence and bleeding. However, warfarin control in CAT patients presented some difficulties. This study also demonstrated the efficacy of anticoagulant drugs, compared with no anticoagulation, for CAT patients to prevent VTE recurrence.

著者

Hirofumi SUGAWARA Ryoko ODA Naoko SEINO

出版者

Meteorological Society of Japan

雑誌

Journal of the Meteorological Society of Japan. Ser. II (ISSN:00261165)

巻号頁・発行日

pp.2018-010, (Released:2017-12-21)

被引用文献数

6

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Does the cities enhance precipitation? It is an unsettled question and the comprehensive answer has not been archived for it. This study focuses on the urban heat excess and evaluates its influence on atmospheric instability which is the background condition for the convective precipitation. A simple approach was developed that involved calculating the daytime evolution of the mixed layer over homogeneous ground surface. Calculations were based on the ensemble average of observations. The convective available potential energy (CAPE) was evaluated for both urban and rural land cover. Urban heat excess, which was 200 W m-2 higher in the urban than rural area, increased CAPE by 75 % comparing to the rural CAPE of 513 J kg-1. Results show that cities could cause favorable stratification of the atmosphere for convective precipitation.