著者

Wakana Katsuta Masahiro Aihara Noboru Hirose Fumiaki Saito Hiroki Hagiwara

出版者

The Society of Physical Therapy Science

雑誌

Journal of Physical Therapy Science (ISSN:09155287)

巻号頁・発行日

vol.30, no.1, pp.42-46, 2018 (Released:2018-01-27)

参考文献数

16

被引用文献数

1

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[Purpose] Changes in oxidative stress severity and antioxidant potential are routinely used as oxidative stress markers. While several studies have reported the relationship between these markers and exercise, little is known about the dynamic nature of these markers during muscle atrophy and reloading. Therefore, we examined changes in oxidative stress severity and antioxidant potential during muscle atrophy and reloading. [Subjects and Methods] Muscle atrophy was induced in mice by casting the limb for 2 weeks. Mice were then subjected to reloading for 2 weeks. The severity of oxidative stress (hydroperoxide) and antioxidant potential (degree of reduction) were quantified. [Results] Muscle atrophy was induced by cast immobilization. The muscle mass of mice recovered to similar levels as the control group following 2 weeks of reloading. The degree of oxidative stress was within the normal range throughout the experimental period. The antioxidant potential decreased to the clinical borderline level 2 weeks after immobilization, further decreased after 1 day of reloading, and then recovered to within the normal range. [Conclusion] Performing d-ROMs and BAP tests may contribute to the understanding to atrophic process of skeletal muscle in clinical practice of physical therapy.

著者

萩原 宏毅 塚田 絵里子 Hiroki HAGIWARA Eriko TSUKADA 帝京科学大学医療科学部作業療法学科 帝京科学大学医療科学部理学療法学科 Department of Occupational Therapy Faculty of Medical Sciences Teikyo University of Science Department of Physical Therapy Faculty of Medical Sciences Teikyo University of Science

雑誌

帝京科学大学紀要 = Bulletin of Teikyo University of Science

巻号頁・発行日

vol.8, pp.1-10, 2012-03-31 (Released:2016-02-15)

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Neurological diseases are one of the most common causes for rehabilitation intervention such as physical therapy, occupational therapy, and speech therapy. Among them, stroke dominates the number of the patients and leading cause of adult disability in Japan. Until recently, there were no established training strategies to recover motor function for such patients. However, the findings from basic neuroscience brought the drastic change of this picture. The most critical and fundamental finding was" neural plasticity". The changes of organization in damaged primary cortex after movement training were demonstrated by using squirrel monkey. In addition, the methods to evaluate brain function such as fMRI, SPECT, PET, fNIRS, EEG, and MEG are developed. Studies in both animal model and patients after brain damage proved the principle that movement training in rehabilitation can modulate cortical plasticity. These results strongly suggest directions in the development of novel strategies to enhance training effects on motor recovery. The rehabilitation aimed to recover movement by inducing cortical plasticity is called as "neurorehabilitation". The most essential problem of neurorehabilitation is how to create to specific learning situations to promote mechanisms of neural plasticity in recovery from brain damage. In this review, we describe the concept of neurorehabilitation, the basic science principles on which they are based, and the current status and future view of clinical applications.