- 著者
- JAMES V. NEEL WILLIAM J. SCHULL AKIO A. AWA CHIYOKO SATOH HIROO KATO MASANORI OTAKE YASUHIKO YOSHIMOTO
- 出版者
- Journal of Radiation Research Editorial Committee
- 雑誌
- Journal of Radiation Research (ISSN:04493060)
- 巻号頁・発行日
- vol.32, no.SUPPLEMENT, pp.347-374, 1991 (Released:2006-05-31)
- 参考文献数
- 75
- 被引用文献数
- 5
The data collected in Hiroshima and Nagasaki during the past 40 years on the children of survivors of the atomic bombings and on the children of a suitable control population are analyzed on the basis of the newly revised estimates of radiation doses. No statistically significant effects emerge with respect to eight different indicators. Since, however, it may confidently be assumed some mutations were induced, we have taken the data at face value and calculated the minimal gametic doubling doses of acute radiation for the individual indicators at various probability levels. An effort has also been made to calculate the most probable doubling dose for the indicators combined. The latter value is between 1.7 and 2.2 Sv. It is suggested the appropriate figure for chronic radiation would be between 3.4 and 4.5 Sv. These estimates suggest humans are less sensitive to the genetic effects of radiation than has been assumed on the basis of past extrapolations from experiments with mice.
- 著者
- SHOICHIRO FUJITA HIROO KATO WILLIAM J. SCHULL
- 出版者
- Journal of Radiation Research 編集委員会
- 雑誌
- Journal of Radiation Research (ISSN:04493060)
- 巻号頁・発行日
- vol.32, no.SUPPLEMENT, pp.154-161, 1991 (Released:2006-05-31)
- 参考文献数
- 24
- 被引用文献数
- 7 14
Numerous attempts have been made to estimate the distance at which 50% of the individuals exposed to the A-bombing of Hiroshima and Nagasaki died, ostensibly from their exposure to ionizing radiation. It is difficult to convert most of these distance estimates to a dose-related LD50, since radiation shielding was ignored. The recent reassessment of the atomic bomb radiation dosimetry has provided an opportunity for the estimation of the bone marrow LD50. There is a surprising concordance in the various estimates that have been made given the different groups of survivors involved and the methods used to estimate the LD50/60.
- 著者
- Yoshihide Kinjo Suminori Akiba Naohito Yamguchi Shoichi Mizuno Shaw Watanabe Junji Wakamiya Makoto Futatsuka Hiroo Kato
- 出版者
- Japan Epidemiological Association
- 雑誌
- Journal of Epidemiology (ISSN:09175040)
- 巻号頁・発行日
- vol.6, no.3, pp.134-138, 1996 (Released:2007-11-30)
- 参考文献数
- 24
- 被引用文献数
- 5 13
We report here a historical cohort study on cancer mortality among Minamata disease (MD) patients (n=1, 351) in Kagoshima and Kumamoto Prefectures of Japan. Taking into account their living area, sex, age and fish eating habits, the residents (n=5, 667; 40 years of age or over at 1966) living in coastal areas of Kagoshima, who consumed fish daily, were selected as a reference group from the six-prefecture cohort study conducted by Hirayama et al. The observation periods of the MD patients and of the reference group were from 1973 to 1984 and from 1970 to 1981, respectively. Survival analysis using the Poisson regression model was applied for comparison of mortality between the MD patients and the reference group. No excess of relative risk (RR) adjusted for attained age, sex and follow-up period was observed for mortality from all causes, all cancers, and non-cancers combined. Analysis of site-specific cancers showed a statistically significant decrease in mortality from stomach cancer among MD patients (RR, 0.49; 95 % confidence interval, 0.26-0.94). In addition, a statistically significant eight-fold excess risk, based on 5 observed deaths, was noted for mortality from leukemia (RR, 8.35; 95 % confidence interval, 1.61-43.3). It is, however, unlikely for these observed risks to be derived from methylmercury exposure only. Further studies are needed to understand the mechanisms involved in the observed risks among MD patients. J Epidemiol, 1996 ; 6 : 134-138.
- 著者
- QUANFU SUN SUMINORI AKIBA ZUFAN TAO YONGLING YUAN JIANMING ZOU HIROSHIGE MORISHIMA HIROO KATO YONGRU ZHA TSUTOMU SUGAHARA LUXIN WEI
- 出版者
- Journal of Radiation Research Editorial Committee
- 雑誌
- Journal of Radiation Research (ISSN:04493060)
- 巻号頁・発行日
- vol.41, no.SUPPL, pp.S43-S52, 2000 (Released:2001-10-19)
- 参考文献数
- 18
- 被引用文献数
- 19
A study was made on cancer mortality in the high-background radiation areas of Yangjiang, China. Based on hamlet-specific environmental doses and sex- and age-specific occupancy factors, cumulative doses were calculated for each subject. In this article, we describe how the indirect estimation was made on individual dose and the methodology used to estimate radiation risk. Then, assuming a linear dose response relationship and using cancer mortality data for the period 1979-1995, we estimate the excess relative risk per Sievert for solid cancer to be -0.11 (95% CI, -0.67, 0.69). Also, we estimate the excess relative risks of four leading cancers in the study areas, i.e., cancers of the liver, nasopharynx, lung and stomach. In addition, we evaluate the effects of possible bias on our risk estimation.