- 著者
- Yoshiki Murakami Masaya Shinohara Yosuke Oka Ryo Wada Ryota Noike Hiroshi Ohara Tadashi Fujino Takanori Ikeda
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- pp.8731-21, (Released:2021-11-27)
- 参考文献数
- 14
- 被引用文献数
- 11
COVID-19 vaccine-related myocarditis has been reported worldwide. We herein report two Japanese cases with suspected vaccine-related myocarditis. A 27-year-old man was admitted with chest pain 4 days after the second vaccination. An electrocardiogram (ECG) did not reveal any significant abnormalities. The second patient, a 37-year-old man, was admitted with chest pain 9 days after the first vaccination. His ECG exhibited ST-elevation in multiple leads. In both cases, cardiac magnetic resonance imaging findings were consistent with myocarditis. They recovered with symptomatic relief within a few days. These cases suggest that the benefit of COVID-19 vaccination exceeds the risk of vaccine-related myocarditis.
- 著者
- HIROSHI OHARA
- 出版者
- Japanese Society of Tropical Medicine
- 雑誌
- Tropical Medicine and Health (ISSN:13488945)
- 巻号頁・発行日
- vol.32, no.3, pp.235-240, 2004 (Released:2004-11-12)
- 参考文献数
- 14
- 被引用文献数
- 9 11
Severe Acute Respiratory Syndrome (SARS) has rapidly spread and caused epidemics in many countries. During these epidemics, the Japanese government contributed to SARS control by dispatching medical teams. In the present article, the author reviews and discusses the process of control of the SARS outbreak based on experiences in activities to support SARS control in Vietnam and China.Vietnam succeeded in the effective control of SARS for the first time in the world. This was accomplished by complete isolation of patients and implementation of nosocomial infection control from an early stage of epidemic, etc. In China, due to inadequate response in the early stage, nosocomial infection occurred frequently and the disease quickly spread. However, later, effective actions were taken under the strong direction of the government, and the disease was finally put under control. The Japan Medical Team for Disaster Relief dispatched by the government of Japan to Hanoi, Vietnam and Beijing, China offered cooperative activities for the prevention of nosocomial infection and respiratory management. In addition, the Medical Aid Team sent to Guangdong Province in China provided guidance to the local Japanese residents to prevent the infection of SARS and to alleviate anxiety about the disease. In the control of SARS, it is essential to take adequate actions from an early stage in the development of the disease. For this purpose, rather than starting measures for the control of nosocomial infection after the eruption of the disease, it is important to train medical staff on a routine basis, to establish a nosocomial infection control system, and to consolidate basic preventive practices.
- 著者
- Yukiko Yamazaki-Hashimoto Yuji Nakamura Hiroshi Ohara Xin Cao Ken Kitahara Hiroko Izumi-Nakaseko Kentaro Ando Hiroshi Yamazaki Takanori Ikeda Junichi Yamazaki Atsushi Sugiyama
- 出版者
- The Japanese Society of Toxicology
- 雑誌
- The Journal of Toxicological Sciences (ISSN:03881350)
- 巻号頁・発行日
- vol.40, no.1, pp.33-42, 2015-02-01 (Released:2014-12-18)
- 参考文献数
- 39
- 被引用文献数
- 9 11
Fluvoxamine is one of the typical selective serotonin-reuptake inhibitors. While its combined use with QT-prolonging drugs has been contraindicated because of the increase in plasma concentrations of such drugs, information is still limited whether fluvoxamine by itself may directly prolong the QT interval. We examined electropharmacological effects of fluvoxamine together with its pharmacokinetic profile by using the halothane-anesthetized dogs (n = 4). Fluvoxamine was intravenously administered in three escalating doses of 0.1, 1 and 10 mg/kg over 10 min with a pause of 20 min between the doses. The low dose provided therapeutic plasma drug concentration, whereas the middle and high doses attained approximately 10 and 100 times of the therapeutic ones, respectively. Supra-therapeutic concentration of fluvoxamine exerted the negative chronotropic, inotropic and hypotensive effects; and suppressed the atrioventricular nodal and intraventricular conductions, indicating inhibitory actions on Ca2+ and Na+ channels, whereas it delayed the repolarization in a reverse use-dependent manner, reflecting characteristics of rapidly activating delayed rectifier K+ current channel-blocking property. Fluvoxamine prolonged the terminal repolarization phase at 100 times higher concentration than the therapeutic, indicating its proarrhythmic potential. Thus, fluvoxamine by itself has potential to directly induce long QT syndrome at supra-therapeutic concentrations.
- 著者
- Yoshiki Murakami Masaya Shinohara Yosuke Oka Ryo Wada Ryota Noike Hiroshi Ohara Tadashi Fujino Takanori Ikeda
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- vol.61, no.4, pp.501-505, 2022-02-15 (Released:2022-02-15)
- 参考文献数
- 14
- 被引用文献数
- 11
COVID-19 vaccine-related myocarditis has been reported worldwide. We herein report two Japanese cases with suspected vaccine-related myocarditis. A 27-year-old man was admitted with chest pain 4 days after the second vaccination. An electrocardiogram (ECG) did not reveal any significant abnormalities. The second patient, a 37-year-old man, was admitted with chest pain 9 days after the first vaccination. His ECG exhibited ST-elevation in multiple leads. In both cases, cardiac magnetic resonance imaging findings were consistent with myocarditis. They recovered with symptomatic relief within a few days. These cases suggest that the benefit of COVID-19 vaccination exceeds the risk of vaccine-related myocarditis.