著者

Atsushi Sugiyama Sue Duval Yuji Nakamura Katsunori Yoshihara Demetris Yannopoulos

出版者

The Japanese Circulation Society

雑誌

Circulation Journal (ISSN:13469843)

巻号頁・発行日

vol.80, no.10, pp.2124-2132, 2016-09-23 (Released:2016-09-23)

参考文献数

42

被引用文献数

7 22

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Background:The quality of cardiopulmonary resuscitation (CPR) has been recently shown to affect clinical outcome. The Resuscitation Outcomes Consortium (ROC) Prehospital Resuscitation Impedance Valve and Early Versus Delayed Analysis (PRIMED) trial showed no differences in outcomes with an active vs. sham impedance threshold device (ITD), a CPR adjunct that enhances circulation. It was hypothesized the active ITD would improve survival with favorable neurological outcomes in witnessed out-of-hospital cardiac arrest patients when used with high-quality CPR.Methods and Results:Using the publicly accessible ROC PRIMED database, a post-hoc analysis was performed on all witnessed subjects with both compression rate and depth data (n=1,808) who received CPR within the study protocol definition of adequate CPR quality (compression rate 80–120/min and depth 4–6 cm; n=929). Demographics were similar between sham and active ITD groups. In witnessed subjects who received quality CPR, survival with favorable neurological function was 11.9% for the active ITD subjects (56/470) vs. 7.4% for the sham (34/459) (odds ratio 1.69 [95% confidence interval 1.08, 2.64]). There were no statistically significant differences for this primary outcome when CPR was performed outside the boundaries of the definition of adequate CPR quality. Multivariable models did not change these associations.Conclusions:An active ITD combined with adequate-quality conventional CPR has the potential to significantly improve survival after witnessed cardiac arrest. (Circ J 2016; 80: 2124–2132)

著者

中村 祐司 Yuji NAKAMURA

出版者

宇都宮大学地域デザイン科学部

雑誌

地域デザイン科学 : 宇都宮大学地域デザイン科学部研究紀要 = Journal of the School of regional design Utsunomiya University (ISSN:24326704)

巻号頁・発行日

no.7, pp.21-34, 2020-02-01

著者

中村 祐司 Yuji NAKAMURA

出版者

宇都宮大学地域デザイン科学部

雑誌

地域デザイン科学 : 宇都宮大学地域デザイン科学部研究紀要 = Journal of the School of Regional Design Utsunomiya University (ISSN:24326704)

巻号頁・発行日

no.8, pp.1-21, 2020-09-01

著者

Yukiko Yamazaki-Hashimoto Yuji Nakamura Hiroshi Ohara Xin Cao Ken Kitahara Hiroko Izumi-Nakaseko Kentaro Ando Hiroshi Yamazaki Takanori Ikeda Junichi Yamazaki Atsushi Sugiyama

出版者

The Japanese Society of Toxicology

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.40, no.1, pp.33-42, 2015-02-01 (Released:2014-12-18)

参考文献数

39

被引用文献数

9 11

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Fluvoxamine is one of the typical selective serotonin-reuptake inhibitors. While its combined use with QT-prolonging drugs has been contraindicated because of the increase in plasma concentrations of such drugs, information is still limited whether fluvoxamine by itself may directly prolong the QT interval. We examined electropharmacological effects of fluvoxamine together with its pharmacokinetic profile by using the halothane-anesthetized dogs (n = 4). Fluvoxamine was intravenously administered in three escalating doses of 0.1, 1 and 10 mg/kg over 10 min with a pause of 20 min between the doses. The low dose provided therapeutic plasma drug concentration, whereas the middle and high doses attained approximately 10 and 100 times of the therapeutic ones, respectively. Supra-therapeutic concentration of fluvoxamine exerted the negative chronotropic, inotropic and hypotensive effects; and suppressed the atrioventricular nodal and intraventricular conductions, indicating inhibitory actions on Ca2+ and Na+ channels, whereas it delayed the repolarization in a reverse use-dependent manner, reflecting characteristics of rapidly activating delayed rectifier K+ current channel-blocking property. Fluvoxamine prolonged the terminal repolarization phase at 100 times higher concentration than the therapeutic, indicating its proarrhythmic potential. Thus, fluvoxamine by itself has potential to directly induce long QT syndrome at supra-therapeutic concentrations.

著者

Toshihiro Akihisa Keiichi Tabata Norihiro Banno Harukuni Tokuda Reiko Nishihara Yuji Nakamura Yumiko Kimura Ken Yasukawa Takashi Suzuki

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.29, no.9, pp.1976-1979, 2006 (Released:2006-09-01)

参考文献数

20

被引用文献数

46 56

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Fifteen triterpene acids, viz., seven of the β-boswellic acids (ursane-type) (1—7), two of the α-boswellic acids (oleanane-type) (8, 9), two of the lupeolic acids (lupane-type) (10, 11), and four of the tirucallane-type (12—14, 16), and two cembrane-type diterpenes (17, 18), isolated from the MeOH extract of the resin of Boswellia carteri (Burseraceae), together with a triterpene acid 15 (the acetyl derivative of 14), were examined for their inhibitory effects on the induction of Epstein–Barr virus early antigen (EBV-EA) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells and on activation of (±)-(E)-methyl-2[(E)-hydroxyimino]-5-nitro-6-methoxy-3-hexemide (NOR 1), a nitrogen oxide (NO) donor, and cytotoxic activities against three human neuroblastoma cell lines, IMR-32, NB-39, and SK-N-SH in vitro. On evaluation against the EBV-EA activation induced by TPA, seven compounds, 2, 10, 11, and 13—16, showed potent inhibitory effects on EBV-EA induction. Upon evaluation against activation of NOR 1, five compounds, 7, 13, and 14—16, showed potent inhibitory effects. Further, fifteen compounds, 1—7, 9—11, 13—15, 17, and 18, exhibited potent cytotoxic activities with IC50 values of 4.1—82.4 μM against all of the three human neuroblastoma cells tested.

著者

中村 祐司 Yuji NAKAMURA

出版者

宇都宮大学地域デザイン科学部

雑誌

地域デザイン科学 : 宇都宮大学地域デザイン科学部研究紀要 = Journal of the School of Regional Design Utsunomiya University (ISSN:24326704)

巻号頁・発行日

no.9, pp.1-21, 2021-02-01

著者

中村 祐司 Yuji NAKAMURA

出版者

宇都宮大学地域デザイン科学部

雑誌

地域デザイン科学 : 宇都宮大学地域デザイン科学部研究紀要 = Journal of the School of Regional Design Utsunomiya University (ISSN:24326704)

巻号頁・発行日

no.8, pp.23-43, 2020-09-01

著者

中村 祐司 Yuji NAKAMURA

出版者

宇都宮大学地域デザイン科学部

雑誌

地域デザイン科学 : 宇都宮大学地域デザイン科学部研究紀要 = Journal of the Faculty of Regional Design Utsunomiya University (ISSN:24326704)

巻号頁・発行日

no.9, pp.1-21, 2021-02

著者

中村 祐司 Yuji NAKAMURA

出版者

宇都宮大学地域デザイン科学部

雑誌

地域デザイン科学 : 宇都宮大学地域デザイン科学部研究紀要 = Journal of the Faculty of Regional Design Utsunomiya University (ISSN:24326704)

巻号頁・発行日

no.9, pp.23-41, 2021-02

著者

中村 祐司 Yuji NAKAMURA

出版者

宇都宮大学国際学部

雑誌

宇都宮大学国際学部研究論集 (ISSN:13420364)

巻号頁・発行日

no.39, pp.77-81, 2015-02

著者

Takeshi Kodama Yuji Nakamura Sonomi Nakajima Kenichi Kamoshita Yasuhito Sengoku

出版者

Japanese Association of Occupational Therapists

雑誌

Asian Journal of Occupational Therapy (ISSN:13473476)

巻号頁・発行日

vol.15, no.1, pp.85-92, 2019 (Released:2019-12-06)

参考文献数

19

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This study investigated the effects of seat cushion material during a reaching task. Ten healthy adults and three individuals with cerebral palsy participated. All subjects performed the reaching task on two urethane cushions and one silicone cushion. Anterior/posterior and medial/lateral displacement of the center of pressure and straight rate were assessed. In addition, the movement trajectory of the hand was recorded. No differences among seat cushions were observed in healthy adults. However, all of individuals with cerebral palsy were able to perform the task more efficiency while seated on the silicone cushion than the others. These findings suggest that seat cushion design may improve movement in individuals with cerebral palsy who have postural control disabilities.

著者

Xin Cao Yuji Nakamura Takeshi Wada Hiroko Izumi-Nakaseko Kentaro Ando Atsushi Sugiyama

出版者

日本毒性学会

雑誌

The Journal of Toxicological Sciences (ISSN:03881350)

巻号頁・発行日

vol.41, no.3, pp.439-447, 2016-06-01 (Released:2016-05-17)

参考文献数

21

被引用文献数

14

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Since amantadine-induced long QT syndrome has been clinically reported, we investigated its electropharmacological effects to estimate the extent of proarrhythmic risk by using the halothane-anesthetized beagle dogs (n = 4). Amantadine in doses of 0.1, 1 and 10 mg/kg was infused over 10 min with a pause of 20 min under the monitoring of multiple cardiovascular variables. J-Tpeak and Tpeak-Tend were separately measured on the lead II electrocardiogram to precisely analyze the net balance between inward and outward current modifications by amantadine. The low dose increased the ventricular contractile force, but suppressed the intraventricular conduction. The middle dose prolonged the QT interval besides enhancing the changes induced by the low dose. The high dose increased the mean blood pressure, left ventricular end-diastolic pressure and total peripheral resistance, and accelerated the atrioventricular nodal conduction, but decreased the cardiac output besides enhancing the changes induced by the middle dose. A reverse use-dependence was confirmed in the repolarization delay. Amantadine hardly affected the J-Tpeak, but prolonged the Tpeak-Tend. Amantadine can be considered to stimulate Ca2+ channel but inhibit Na+ and K+ channels in the in situ heart. J-Tpeak and Tpeak-Tend analysis suggests that amantadine may possess modest risk for arrhythmia.