- 著者
- Yasuhiro Oda Yoichiro Ikeda Hiroyuki Abe Akinori Hashiguchi Kazuhito Hatanaka Toshihiro Sawai Tetsuo Ushiku Masaomi Nangaku
- 出版者
- The Japanese Society of Internal Medicine
- 雑誌
- Internal Medicine (ISSN:09182918)
- 巻号頁・発行日
- pp.1117-22, (Released:2023-04-28)
- 参考文献数
- 3
An 84-year-old man developed a membranoproliferative glomerulonephritis pattern of injury, and the most likely cause detected during a workup was monoclonal IgG-λ in the urine and serum. Predominant IgG and λ light chain deposition was confirmed only by immunofluorescence using formalin-fixed, paraffin-embedded tissue and not by immunohistochemistry. A smaller and non-linear dynamic range of immunohistochemistry makes it less quantitative than immunofluorescence staining and may explain why immunohistochemistry failed to detect the light chain restriction. This case suggests that immunohistochemistry may not serve as a substitute for immunofluorescence on formalin-fixed, paraffin-embedded tissue in detecting masked monoclonal immunoglobulin deposits, although further research is warranted.
- 著者
- 阿部 宏行 花輪 大輔 Hiroyuki Abe Hanawa Daisuke
- 出版者
- 札幌大学女子短期大学部
- 雑誌
- 札幌大学女子短期大学部紀要 = Sapporo University women's junior college Journal
- 巻号頁・発行日
- vol.70, pp.149-173, 2022-03
- 著者
- Minako Abe Hiroyuki Abe
- 出版者
- International Society of Personalized Medicne
- 雑誌
- Personalized Medicine Universe (ISSN:21864969)
- 巻号頁・発行日
- vol.9, pp.10-14, 2020-10-31 (Released:2020-12-01)
- 参考文献数
- 47
Immune resilience is the ability for the human body to adapt and respond to adverse conditions, such as bacterial pathogens, viral infections, and abnormal or cancerous cells. Our ability to mount an appropriate response against such illness relates directly to our level of immune resilience, which in turn is impacted by our lifestyle choices. Nutrition, exercise, sleep and stress management are powerful influencers of mucosal immunity, the first line of defense against pathogens, and the exposome, exogenous and endogenous factors affecting our overall health. Lifestyle medicine offers evidence-based recommendations on how to optimize our immune system to withstand and thwart infections and disease.
- 著者
- Shun Minatsuki Ichiro Miura Atsushi Yao Hiroyuki Abe Hironori Muraoka Mariko Tanaka Teruhiko Imamura Toshiro Inaba Hisataka Maki Masaru Hatano Koichiro Kinugawa Takashi Yao Masashi Fukayama Ryozo Nagai Issei Komuro
- 出版者
- 一般社団法人 インターナショナル・ハート・ジャーナル刊行会
- 雑誌
- International Heart Journal (ISSN:13492365)
- 巻号頁・発行日
- pp.14-220, (Released:2015-02-23)
- 被引用文献数
- 2 40
Pulmonary hypertension (PH) induced by pulmonary tumor thrombotic microangiopathy (PTTM) can be fatal because its rapid progression confounds diagnosis, and it is difficult to control with therapy. Here we describe a woman with symptomatic PTTM-PH accompanying gastric cancer that was suspected from perfusion scintigraphy. PTTM-PH was diagnosed by gastroesophageal endoscopy and lung biopsy after partial control of PH using the platelet-derived growth factor (PDGF) receptor (PDGFR) tyrosine kinase inhibitor, imatinib. Treatment with sildenafil and ambrisentan further decreased PH, and she underwent total gastrectomy followed by adjuvant TS-1 chemotherapy. PH did not recur before her death from metastasis. Postmortem histopathology showed recanalized pulmonary arteries where the embolized cancer masses disappeared. PDGF-A, -B, and PDGFR-α, β expression was detected in cancer cells and proliferating pulmonary vascular endothelial cells. Thus, PTTM-PH was successfully controlled using a combination of imatinib, drugs to treat pulmonary arterial hypertension, and cancer management.