著者

Akihiro Hirashiki Atsuya Shimizu Noriyuki Suzuki Kenichiro Nomoto Manabu Kokubo Kakeru Hashimoto Kenji Sato Izumi Kondo Toyoaki Murohara Hidenori Arai

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.4, no.3, pp.123-130, 2022-03-10 (Released:2022-03-10)

参考文献数

38

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Background:The relationship between frailty status and laboratory measurements in cardiovascular disease (CVD) remains unclear. We investigated which laboratory measurements indicated frailty in stable older CVD patients.Methods and Results:One-hundred thirty-eight stable older CVD patients were evaluated by laboratory measurements, with frailty assessed using the Kihon Checklist (KCL). Laboratory measurements were compared between frail and non-frail groups. Across the entire cohort, mean age was 81.7 years, mean left ventricular ejection fraction was 57.8%, and mean plasma B-type natriuretic peptide was 182 pg/mL. KCL scores were used to divide patients into non-frail (n=43; KCL <8) and frail (n=95; KCL ≥8) groups. Serum iron was significantly lower in the frail than non-frail group (mean [±SD] 61.2±30.3 vs. 89.5±26.1 μg/dL, respectively; P<0.001). Blood urea nitrogen (BUN; 27.3±16.5 vs. 19.7±8.2 mg/dL; P=0.013) and C-reactive protein (CRP; 1.05±1.99 vs. 0.15±0.21 mg/dL; P=0.004) were significantly higher in the frail than non-frail group. Multivariate analysis revealed that serum iron, CRP, and BUN were significant independent predictors of frailty (β=−0.069, 0.917, and 0.086, respectively).Conclusions:Frailty status was significantly associated with iron, CRP, and BUN in stable older CVD patients. Composite biomarkers (inflammation, iron deficiency, and renal perfusion) may be useful for assessing frailty in these patients.

著者

Hiroyuki Miyasaka Wataru Narita Yuuki Nakagawa Rieko Kanamori Maki Ohshita Satsuki Kawakami Koji Shimomura Izumi Kondo Shigeru Sonoda

出版者

一般社団法人 回復期リハビリテーション病棟協会

雑誌

Japanese Journal of Comprehensive Rehabilitation Science (ISSN:21855323)

巻号頁・発行日

vol.7, pp.61-72, 2016 (Released:2016-09-09)

参考文献数

30

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Miyasaka H, Narita W, Nakagawa Y, Kanamori R, Ohshita M, Kawakami S, Shimomura K, Kondo I, Sonoda S. Development and validity of an evaluation of higher cortical dysfunction in the daily life of patients with stroke and traumatic brain injury. Jpn J Compr Rehabil Sci 2016; 7: 61-72.Purpose: To develop a valid Cognition-oriented Performance Evaluation (COPE) questionnaire for the evaluation of higher brain function in any environment using the nominal group technique (NGT).Method: The NGT participants included nine expert staff members of our hospital. The NGT process was performed twice and involved: 1) enumerating questions regarding the presence or absence of higher cortical dysfunction symptoms, 2) judging each item on a four-point scale and posing additional questions, 3) determining the level of agreement across participants using the NGT, and 4) modifying, removing, and adding questions based on the agreement and comments of the NGT participants. In addition, a correlation analysis between COPE areas and the social cognition items of the Functional Independence Measure (FIM) was performed in 20 patients with higher cortical dysfunction.Results and discussion: An initial 126 questions were crafted prior to the NGT. During the first NGT, 12 items failed to achieve adequate agreement, and during the second NGT, three items failed. Furthermore, we coordinated the expressed opinions after the second NGT. The final version contained 96 items. Correlation analysis demonstrated significant correlation between the COPE and FIM in related items such as memory and problem-solving. Thus, the validity of the COPE was verified using a qualitative research technique (consensus method) and by correlation with another scale.

著者

Akihiro Hirashiki Atsuya Shimizu Noriyuki Suzuki Kenichiro Nomoto Manabu Kokubo Kakeru Hashimoto Kenji Sato Izumi Kondo Toyoaki Murohara Hidenori Arai

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-21-0143, (Released:2022-02-05)

参考文献数

38

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Background:The relationship between frailty status and laboratory measurements in cardiovascular disease (CVD) remains unclear. We investigated which laboratory measurements indicated frailty in stable older CVD patients.Methods and Results:One-hundred thirty-eight stable older CVD patients were evaluated by laboratory measurements, with frailty assessed using the Kihon Checklist (KCL). Laboratory measurements were compared between frail and non-frail groups. Across the entire cohort, mean age was 81.7 years, mean left ventricular ejection fraction was 57.8%, and mean plasma B-type natriuretic peptide was 182 pg/mL. KCL scores were used to divide patients into non-frail (n=43; KCL <8) and frail (n=95; KCL ≥8) groups. Serum iron was significantly lower in the frail than non-frail group (mean [±SD] 61.2±30.3 vs. 89.5±26.1 μg/dL, respectively; P<0.001). Blood urea nitrogen (BUN; 27.3±16.5 vs. 19.7±8.2 mg/dL; P=0.013) and C-reactive protein (CRP; 1.05±1.99 vs. 0.15±0.21 mg/dL; P=0.004) were significantly higher in the frail than non-frail group. Multivariate analysis revealed that serum iron, CRP, and BUN were significant independent predictors of frailty (β=−0.069, 0.917, and 0.086, respectively).Conclusions:Frailty status was significantly associated with iron, CRP, and BUN in stable older CVD patients. Composite biomarkers (inflammation, iron deficiency, and renal perfusion) may be useful for assessing frailty in these patients.