著者

Hideaki Sasaki Susumu Shirato Tomoya Tahara Kenji Sato Hiroyuki Takenaka

出版者

日本微生物生態学会 / 日本土壌微生物学会 / Taiwan Society of Microbial Ecology / 植物微生物研究会

雑誌

Microbes and Environments (ISSN:13426311)

巻号頁・発行日

pp.ME13035, (Released:2013-11-19)

被引用文献数

2 20

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The Fukushima Daiichi Nuclear Power Plant accident released large amounts of radioactive substances into the environment and contaminated the soil of Tohoku and Kanto districts in Japan. Removal of radioactive material from the environment is an urgent problem, and soil purification using plants is being considered. In this study, we investigated the ability of 12 seed plant species and a cyanobacterium to accumulate radioactive material. The plants did not accumulate radioactive material at high levels, but high accumulation was observed in the terrestrial cyanobacterium Nostoc commune. In Nihonmatsu City, Fukushima Prefecture, N. commune accumulated 415,000 Bq/kg dry weight 134Cs and 607,000 Bq kg-1 dry weight 137Cs. The concentration of cesium in N. commune tended to be high in areas where soil radioactivity was high. A cultivation experiment confirmed that N. commune absorbed radioactive cesium from polluted soil. These data demonstrated that radiological absorption using N. commune might be suitable for decontaminating polluted soil.

著者

Akihiro Hirashiki Atsuya Shimizu Noriyuki Suzuki Kenichiro Nomoto Manabu Kokubo Kakeru Hashimoto Kenji Sato Izumi Kondo Toyoaki Murohara Hidenori Arai

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

vol.4, no.3, pp.123-130, 2022-03-10 (Released:2022-03-10)

参考文献数

38

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Background:The relationship between frailty status and laboratory measurements in cardiovascular disease (CVD) remains unclear. We investigated which laboratory measurements indicated frailty in stable older CVD patients.Methods and Results:One-hundred thirty-eight stable older CVD patients were evaluated by laboratory measurements, with frailty assessed using the Kihon Checklist (KCL). Laboratory measurements were compared between frail and non-frail groups. Across the entire cohort, mean age was 81.7 years, mean left ventricular ejection fraction was 57.8%, and mean plasma B-type natriuretic peptide was 182 pg/mL. KCL scores were used to divide patients into non-frail (n=43; KCL <8) and frail (n=95; KCL ≥8) groups. Serum iron was significantly lower in the frail than non-frail group (mean [±SD] 61.2±30.3 vs. 89.5±26.1 μg/dL, respectively; P<0.001). Blood urea nitrogen (BUN; 27.3±16.5 vs. 19.7±8.2 mg/dL; P=0.013) and C-reactive protein (CRP; 1.05±1.99 vs. 0.15±0.21 mg/dL; P=0.004) were significantly higher in the frail than non-frail group. Multivariate analysis revealed that serum iron, CRP, and BUN were significant independent predictors of frailty (β=−0.069, 0.917, and 0.086, respectively).Conclusions:Frailty status was significantly associated with iron, CRP, and BUN in stable older CVD patients. Composite biomarkers (inflammation, iron deficiency, and renal perfusion) may be useful for assessing frailty in these patients.

著者

Kenji Sato Hirokazu Kato Takafumi Fukushima

出版者

The Institute of Electrical Engineers of Japan

雑誌

IEEJ Journal of Industry Applications (ISSN:21871094)

巻号頁・発行日

vol.10, no.4, pp.402-410, 2021-07-01 (Released:2021-07-01)

参考文献数

20

被引用文献数

21

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This paper overviews a traction system for Tokaido Shinkansen trains and presents a novel silicon carbide (SiC)-applied traction system of the new generation Shinkansen train, “N700S”, which began commercial service in the summer of 2020. To achieve compactness and weight reduction, N700S's traction system aimed to take advantage of the merits of SiC devices, which have a lower power loss, higher frequency, and a higher current than Si devices, not only in the conversion system but also in the entire traction system. This weight reduction and compactness allowed for flexibility in the design of underfloor equipment of the car body and enabled the realization of a lithium-ion battery self-traction system that could operate catenary-free at low speeds in the event of a power outage. It also contributed toward achieving flexibility by the easy redesign of different configurations of trains such as 8-car or 12-car sets rather than the standard 16-car trains used for the Tokaido Shinkansen, the concept of which is referred to as the “Standardized Shinkansen train”. The continuous introduction of energy-saving Shinkansen trains including N700S has also led to a decrease in Tokaido Shinkansen's energy consumption. This is the first application of an SiC device and a lithium-ion battery to a high-speed train's traction system in the world.

著者

Hideaki Sasaki Susumu Shirato Tomoya Tahara Kenji Sato Hiroyuki Takenaka

出版者

日本微生物生態学会 / 日本土壌微生物学会 / Taiwan Society of Microbial Ecology / 植物微生物研究会

雑誌

Microbes and Environments (ISSN:13426311)

巻号頁・発行日

vol.28, no.4, pp.466-469, 2013 (Released:2013-12-20)

参考文献数

16

被引用文献数

2 20

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The Fukushima Daiichi Nuclear Power Plant accident released large amounts of radioactive substances into the environment and contaminated the soil of Tohoku and Kanto districts in Japan. Removal of radioactive material from the environment is an urgent problem, and soil purification using plants is being considered. In this study, we investigated the ability of 12 seed plant species and a cyanobacterium to accumulate radioactive material. The plants did not accumulate radioactive material at high levels, but high accumulation was observed in the terrestrial cyanobacterium Nostoc commune. In Nihonmatsu City, Fukushima Prefecture, N. commune accumulated 415,000 Bq/kg dry weight 134Cs and 607,000 Bq kg-1 dry weight 137Cs. The concentration of cesium in N. commune tended to be high in areas where soil radioactivity was high. A cultivation experiment confirmed that N. commune absorbed radioactive cesium from polluted soil. These data demonstrated that radiological absorption using N. commune might be suitable for decontaminating polluted soil.

著者

Kenji Sato Hirokazu Kato Takafumi Fukushima

出版者

The Institute of Electrical Engineers of Japan

雑誌

IEEJ Journal of Industry Applications (ISSN:21871094)

巻号頁・発行日

vol.9, no.4, pp.453-459, 2020-07-01 (Released:2020-07-01)

参考文献数

8

被引用文献数

1 16

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This paper presents the development of a traction system for high-speed trains by adopting SiC power devices to pursue weight reduction and compactness of the system. We found that the combination of the SiC applied conversion system with a blower-less cooling system and 6-pole induction motors is a suitable approach to highlight the merits of SiC devices. The running tests of a prototype were conducted to confirm its sound performances. The developed traction system is installed in the latest type of Shinkansen train, or the Series N700S, which debuted in March 2018 and will enter commercial service in the summer of 2020. This SiC application to the high-speed train's traction system is the first in the world.

著者

Akihiro Hirashiki Atsuya Shimizu Noriyuki Suzuki Kenichiro Nomoto Manabu Kokubo Kakeru Hashimoto Kenji Sato Izumi Kondo Toyoaki Murohara Hidenori Arai

出版者

The Japanese Circulation Society

雑誌

Circulation Reports (ISSN:24340790)

巻号頁・発行日

pp.CR-21-0143, (Released:2022-02-05)

参考文献数

38

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Background:The relationship between frailty status and laboratory measurements in cardiovascular disease (CVD) remains unclear. We investigated which laboratory measurements indicated frailty in stable older CVD patients.Methods and Results:One-hundred thirty-eight stable older CVD patients were evaluated by laboratory measurements, with frailty assessed using the Kihon Checklist (KCL). Laboratory measurements were compared between frail and non-frail groups. Across the entire cohort, mean age was 81.7 years, mean left ventricular ejection fraction was 57.8%, and mean plasma B-type natriuretic peptide was 182 pg/mL. KCL scores were used to divide patients into non-frail (n=43; KCL <8) and frail (n=95; KCL ≥8) groups. Serum iron was significantly lower in the frail than non-frail group (mean [±SD] 61.2±30.3 vs. 89.5±26.1 μg/dL, respectively; P<0.001). Blood urea nitrogen (BUN; 27.3±16.5 vs. 19.7±8.2 mg/dL; P=0.013) and C-reactive protein (CRP; 1.05±1.99 vs. 0.15±0.21 mg/dL; P=0.004) were significantly higher in the frail than non-frail group. Multivariate analysis revealed that serum iron, CRP, and BUN were significant independent predictors of frailty (β=−0.069, 0.917, and 0.086, respectively).Conclusions:Frailty status was significantly associated with iron, CRP, and BUN in stable older CVD patients. Composite biomarkers (inflammation, iron deficiency, and renal perfusion) may be useful for assessing frailty in these patients.

著者

Saki Shirako Kenji Sato Saki Moriwaki Yukinobu Ikeya Mikio Nishizawa

出版者

The Pharmaceutical Society of Japan

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.45, no.2, pp.169-177, 2022-02-01 (Released:2022-02-01)

参考文献数

29

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Many constituents of crude drugs in Japanese Kampo formulas are thought to function as pro-drugs, whose pharmacological activity is manifested after oral administration. Proteins and peptides in crude drugs may be digested and metabolized in the digestive tract and liver. However, few studies have reported the pharmacological activity of peptides in crude drugs. Here, we applied an analysis using LC–tandem mass spectrometry (LC-MS/MS) to identify the compounds derived from six crude drugs that are assumed to have anti-inflammatory effects. To simulate in vivo protease digestion, each water-soluble fraction of the crude drug extracts was treated with proteases, including endoproteinases and exopeptidases. Amines in the resultant digests were modified by 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate and analyzed using LC-MS/MS, which demonstrated the presence of four decarboxylated amino acids (primary amines). In the digest of the hydrophilic fraction of the fruit of Ziziphus jujuba Miller var. inermis Rehder (Taiso), isobutylamine, isoamylamine, and 2-methylbutylamine were identified, which may be derived from valinyl, leucinyl, and isoleucinyl residues, respectively. Additionally, tyramine possibly derived from tyrosyl residues was identified in the digests of all the crude drugs. In primary cultured rat hepatocytes treated with interleukin-1β, all these decarboxylated amino acids suppressed the production of nitric oxide, a proinflammatory mediator. Our approach, i.e., in vitro protease digestion and LC-MS/MS analysis, suggests that decarboxylated amino acids may be formed in vivo from peptides and may be responsible for the anti-inflammatory effect of crude drugs included in Kampo medicine.

著者

佐藤 健司 Kenji Sato

出版者

同志社大学商学会

雑誌

同志社商学 = Doshisha Shogaku (The Doshisha Business Review) (ISSN:03872858)

巻号頁・発行日

vol.72, no.5, pp.733-749, 2021-03-12

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本稿では、日本企業の職場における人間関係に関する従業員の満足度やストレスの状況について確認したうえで、これまでの日本企業における働き方がどのような考えや慣行のもとで構築されていたのかということについて分析する。そしてそうした分析に基づいて、今日の日本企業において生じている働き方や人間関係の問題を解決するためには、どのような点に留意すべきなのかということについて、ジョブ型雇用の考え方と関連させながら考察を行う。

著者

早川 裕隆 小宮 健 田村 博久 佐藤 賢治 岩城 淑樹 林 泰成 Hirotaka HAYAKAWA Tsuyoshi KOMIYA Hirohisa TAMURA Kenji SATO Yoshiki IWAKI Yasunari HAYASHI

出版者

上越教育大学

雑誌

上越教育大学教職大学院研究紀要 = Bulletin of Teaching Profession Graduate School Joetsu University of Education (ISSN:24359637)

巻号頁・発行日

no.8, pp.99-110, 2021-02-28