著者

Zheng Zhihui Yang Yi Shao Huayi Liu Zongying Lu Xinhua Xu Yanni He Xiaobo Jiang Wei Jiang Qin Zhao Baohua Zhang Hua Li Zhuorong Si Shuyi

出版者

公益社団法人 日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.34, no.10, pp.1631-1634, 2011

被引用文献数

6

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In our previous study, two synthetic thiophenes such as IMB-05 and IMB-15 were found as peroxisome proliferator-activated receptor gamma (PPARγ) agonists and exhibited beneficial effects on glucose tolerance of diabetic mice <i>in vivo</i>. In the present study, their effect on the transactivity of other nuclear receptors was further investigated. IMB-05 and IMB-15 could not only activated PPARγ but also efficiently activate PPARα in GAL4-hPPARα/γ (ligand binding domain (LBD)) chimeric receptor assay and PPAR response element (PPRE)-luc reporter gene assay with EC₅₀ values of 1.8—5.2 μ<small>M</small>, whereas no activity was observed in other nuclear receptor assays. In addition, the maximal efficacy of IMB-05 and IMB-15 in activating PPARα/γ was approximately 30% of that observed with Wy14643 and rosiglitazone. These data indicate that the two thiophene derivatives are novel class of partial PPARα/γ dual agonists, which may be the mechanism underlying their regulatory effects on glucose homeostasis.

著者

Song Chun-Feng Kitamura Yutaka Li Shu-Hong Jiang Wei-Zhong

出版者

Elsevier

雑誌

International journal of greenhouse gas control (ISSN:17505836)

巻号頁・発行日

vol.13, pp.26-33, 2013-03

被引用文献数

34 5

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With the development of CO2 capture technologies, the cryogenic approach provides a promising alternative for greenhouse effect mitigation. In previous work, a novel CO2 capture process was developed based on Stirling coolers (SC). However, the properties of frosted CO2 that deposits onto the heat exchanger of SC are not completely understood but it plays an important role as a heat transfer medium and affects subsequent CO2 deposition. In order to improve the system performance and capture efficiency, a thorough analysis of the CO2 frost process becomes especially significant. Based on this aim, numerical and experimental analysis of CO2 frost formation in the cryogenic capture process has been investigated in the present work. The results show that the frosted CO2 layer significantly influences the heat transfer between the gas stream and cooling fins. Over time (from 0 to 60 min), the thickness of the frost layer increased from 0 to 3.0 mm. The thermal conductivity increased from 0 to 0.4 W/(m K). When the flow rate was set at 1 L/min, the temperature of the cold head of the SC varied from −105.2 °C to −102.1 °C. When the flow rate was 3 L/min, the temperature rose from −106.3 °C to −98.0 °C.