著者

Jun Miyata Hirotomo Yamanashi Shin-Ya Kawashiri Sakiko Soutome Kazuhiko Arima Mami Tamai Fumiaki Nonaka Yukiko Honda Masayasu Kitamura Koji Yoshida Yuji Shimizu Naomi Hayashida Shigeru Kawakami Noboru Takamura Takashi Sawase Atsutoshi Yoshimura Yasuhiro Nagata Mayumi Ohnishi Kiyoshi Aoyagi Atsushi Kawakami Toshiyuki Saito Takahiro Maeda

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20230079, (Released:2023-07-29)

参考文献数

42

被引用文献数

1

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In an aging society, it is important to visualize the conditions of people living with diseases or disabilities, such as frailty and sarcopenia, and determine the environmental and genetic factors underlying such conditions. Atherosclerosis and arterial stiffness are key conditions between these factors and noncommunicable diseases. In 2014, we launched a population-based prospective open-cohort study, the Nagasaki Islands Study (NaIS), which was conducted in Goto City, located in the remote islands of Nagasaki Prefecture, Japan, mostly involving middle-aged and older residents. We conducted our own health checkups along with the annual standardized checkups organized by the municipality; recruited study participants; and started to follow-up with them for vital status (death), migration, and occurrence of diseases such as myocardial infarction, stroke, fracture, and human T-cell leukemia virus type 1 (HTLV-1) -associated uveitis. Our checkups were conducted as baseline surveys in different areas of Goto City during the fiscal years 2014–2016, secondary surveys during 2017–2019, and tertiary surveys since 2021, consisting of medical interviews, physical examinations, blood and urine tests, body composition measurements, osteoporosis screening, arterial stiffness measurements, carotid ultrasonography, and dental examination. A total of 4,957 residents participated in either the baseline or secondary surveys and were followed-up; and 3,594 and 3,364 residents (aged 27–96 and 28–98 years) participated in the baseline and secondary surveys, respectively. In conclusion, the NaIS has been undertaken to reveal the influence of aging and risk factors of noncommunicable diseases and disabilities, with an aim to contribute towards better healthcare in the future.

著者

Chie Watanabe Yoshifumi Kimizuka Yuji Fujikura Takaaki Hamamoto Akira Watanabe Takashi Yaguchi Tomoya Sano Ryohei Suematsu Yoshiki Kato Jun Miyata Susumu Matsukuma Akihiko Kawana

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.7639-21, (Released:2021-10-26)

参考文献数

29

被引用文献数

3

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A 69-year-old woman who had undergone renal transplantation and was receiving sulfamethoxazole/trimethoprim (ST) developed pulmonary nocardiosis. To our knowledge, this is the first report of the identification of Nocardia elegans using nanopore sequencing, supported by 16S rDNA capillary sequencing findings. Chest computed tomography performed after ST initiation revealed significant improvement of the pulmonary shadows compared to previous findings. We herein report the value of nanopore sequencing for rapid identification of rare pathogens, such as Nocardia elegans. Furthermore, our findings suggest that Nocardia may infect even patients receiving ST, which is currently the most effective prophylactic drug.

著者

Hisashi Sasaki Yoshifumi Kimizuka Hiraku Ogata Yosuke Okada Shinichiro Ota Tomoya Sano Chie Watanabe Yohei Maki Takayuki Yamamoto Yoichi Tagami Jun Miyata Nobuyoshi Hayashi Yuji Fujikura Akihiko Kawana

出版者

The Japanese Society of Internal Medicine

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

pp.3002-19, (Released:2019-07-10)

参考文献数

14

被引用文献数

6

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Dasatinib-related chylothorax is a rare adverse event, and the mechanism underlying its occurrence is still not fully understood. We herein report the case of a 73-year-old woman with chronic myeloid leukemia (CML) who developed dasatinib-related chylothorax refractory to conventional treatments, except for steroids. To the best of our knowledge, this is the first case of dasatinib-related chylothorax which was successfully controlled by combining diuretics with the Japanese herbal medicine "Goreisan." "Goreisan" is known to inhibit aquaporin channels and regulate the water flow. Our findings showed that "Goreisan" is an effective treatment option for uncontrollable dasatinib-related chylothorax.