著者

KATSU ISHIGAKI HIROYUKI NAMBA NOBORU TAKAMURA HIROKAZU SAIWAI VLADIMIR PARSHIN TOSHINORI OHASHI TAKASHI KANEMATSU SHUNICHI YAMASHITA

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.48, no.5, pp.591-595, 2001 (Released:2006-11-25)

参考文献数

13

被引用文献数

17 21

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We evaluated the incidence of childhood thyroid diseases and urinary iodine levels in Nagasaki, Japan and in Gomel, Belarus, which was greatly radio-contaminated by the Chernobyl accident, in order to obtain the comparative data of thyroid diseases between iodine-rich (Japan) and -deficient (Belarus) areas. In Nagasaki, the median level of urinary iodine, measured by ammonium persulfate digestion in microplate method, was 362.9μg/L. In order to evaluate the geographical differences in Japan, other samples were collected in Hamamatsu and in South Kayabe, Hokkaido, where the median levels were 208.4μg/L and 1015.5μg/L, respectively. Furthermore, thyroid screening by ultrasound (US) in Nagasaki revealed only four cases that showed goiter (1.6%) and two cases (0.8%) that had cystic degeneration and single thyroid cyst. There was no evidence of thyroid nodule detected by US examination. In contrast, the median of urinary iodine level was 41.3μg/L in Gomel. The incidences of goiter (13.6%) and echogenic abnormality (1.74%) in Gomel were much higher than in Nagasaki, suggesting the critical involvement of iodine deficiency in increased childhood thyroid abnormality around Chernobyl. Radioactive iodine released just after the Chernobyl accident may have influenced predominantly children residing in iodine-deficient areas. Our results suggest that management of thyroid screening for schoolchildren at ordinary times may be beneficial for monitoring the adverse effects of radioactive iodine from the standpoint of future prospective study.

著者

HIROKI SHIMURA SHINICHI SUZUKI TOSHIHIKO FUKUSHIMA SANAE MIDORIKAWA SATORU SUZUKI NAOMI HAYASHIDA MISA IMAIZUMI NORIYUKI OKUBO YASUSHI ASARI TAKESHI NIGAWARA FUMIHIKO FURUYA KAZUHIKO KOTANI SHIGEYUKI NAKAJI AKIRA OTSURU TAKASHI AKAMIZU MASAFUMI KITAOKA NOBORU TAKAMURA MASAFUMI ABE HITOSHI OHTO NOBUYUKI TANIGUCHI SHUNICHI YAMASHITA

出版者

福島医学会

雑誌

FUKUSHIMA JOURNAL OF MEDICAL SCIENCE (ISSN:00162590)

巻号頁・発行日

pp.2014-28, (Released:2014-12-20)

参考文献数

33

被引用文献数

4

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Contents1. Introduction2. Thyroid ultrasound examination in Fukushima3. Thyroid ultrasound findings in children in three Japanese prefectures4. Prevalence of thyroid nodular lesions in children and adolescents 4.1 Thyroid cyst 4.2 Thyroid nodule 4.3 Thyroid cancer5. SummaryConflict of interestReference

著者

Naomi HAYASHIDA Yui SEKITANI Alexander KOZLOVSKY Ruslan RAFALSKY Alexander GUTEVICH Valery DANILIUK Shunichi YAMASHITA Noboru TAKAMURA

出版者

Journal of Radiation Research Editorial Committee

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.52, no.5, pp.629-633, 2011 (Released:2011-09-27)

参考文献数

12

被引用文献数

13 4

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During the Chernobyl Nuclear Power Plant (CNPP) accident on 26 April 1986, large amounts of radionuclides were released and spread to vast areas. Inhabitants residing around CNPP have been exposed to external and internal irradiation due to the long half-life of 137Cs (30 years). In this study, we screened for internal whole-body 137Cs concentration using a whole-body counter in the Zhitomir state of Ukraine. The total number of participants was 144,972 (96,149 females and 48,823 males). The median body burden of 137Cs per body weight decreased from 1996 to 2008. In particular, after 2003, more than half of subjects had internal exposure doses below the detectable level. A weak seasonal effect was found in measurement data from 1997 to 1999, but no such effects were observed in later years. We also calculated annual dose for each year and confirmed that doses have been decreasing gradually. In particular, after 2003, the annual effective dose decreased to 0.1 mSv y–1 for 95% of the participants. Only two persons were found to have received more than 5 mSv y–1 since 2007. Although the health effects of 137Cs body burden due to the Chernobyl accident remain uncertain, further screening is needed to monitor the health status and to allay the anxiety of inhabitants in the contaminated areas around CNPP.

著者

NOBORU TAKAMURA SHUNICHI YAMASHITA

出版者

THE FUKUSHIMA SOCIETY OF MEDICAL SCIENCE

雑誌

FUKUSHIMA JOURNAL OF MEDICAL SCIENCE (ISSN:00162590)

巻号頁・発行日

vol.57, no.2, pp.81-85, 2012 (Released:2012-02-22)

参考文献数

9

被引用文献数

8 10

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The Chernobyl disaster on April 26th, 1986, led to the emission of radioactive substances such as iodine-131 and radioactive cesium. As the Soviet Union did not control food distribution and intake, residents were exposed to high levels of internal radiation, leading to the internal radiation exposure of the thyroid gland by iodine 131. As a result, the number of people who had thyroid cancer increased drastically among those who had been under 15 years old at the time of the accident. The age predilection is about to move to 25 or older. However, there has been no scientific evidence of impacts for solid tumor other than thyroid cancer, leukemia, benign diseases, or inheritance including unborn babies. On the other hand, the accident was thought to have caused social unrest and mental damage which had far more impact than that caused by radiation exposure.In this paper, we would like to summarize the impacts on the health of the people in Chernobyl compared to those caused by the accident at the Fukushima Daiichi Nuclear Power Plant.

著者

HIROKI SHIMURA SHINICHI SUZUKI TOSHIHIKO FUKUSHIMA SANAE MIDORIKAWA SATORU SUZUKI NAOMI HAYASHIDA MISA IMAIZUMI NORIYUKI OKUBO YASUSHI ASARI TAKESHI NIGAWARA FUMIHIKO FURUYA KAZUHIKO KOTANI SHIGEYUKI NAKAJI AKIRA OTSURU TAKASHI AKAMIZU MASAFUMI KITAOKA NOBORU TAKAMURA MASAFUMI ABE HITOSHI OHTO NOBUYUKI TANIGUCHI SHUNICHI YAMASHITA

出版者

THE FUKUSHIMA SOCIETY OF MEDICAL SCIENCE

雑誌

FUKUSHIMA JOURNAL OF MEDICAL SCIENCE (ISSN:00162590)

巻号頁・発行日

vol.60, no.2, pp.196-202, 2014 (Released:2015-02-26)

参考文献数

33

被引用文献数

4

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Contents1. Introduction2. Thyroid ultrasound examination in Fukushima3. Thyroid ultrasound findings in children in three Japanese prefectures4. Prevalence of thyroid nodular lesions in children and adolescents 4.1 Thyroid cyst 4.2 Thyroid nodule 4.3 Thyroid cancer5. SummaryConflict of interestReference

著者

Tatiana A. Leonova Valentina M. Drozd Vladimir A. Saenko Mariko Mine Johannes Biko Tatiana I. Rogounovitch Noboru Takamura Christoph Reiners Shunichi Yamashita

出版者

(社)日本内分泌学会

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ14-0408, (Released:2014-11-05)

被引用文献数

3

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Long-term management of patients with differentiated thyroid cancer (DTC) commonly includes TSH-suppressive therapy with L-T4 and, in case of postsurgical hypoparathyroidism, Calcium-D3 supplementation, both of which may affect skeletal health. Experience with female patients treated for DTC at a young age and who were then receiving long-term therapy with L-T4 and Calcium-D3 medication is very limited to date. This cross-sectional study set out to investigate effects of Calcium-D3 supplementation and TSH-suppressive therapy on bone mineral density (BMD) in 124 young female patients treated for DTC at a mean age of 14 years and followed-up for an average of 10 years. BMD was found to be significantly higher in patients receiving Calcium-D3 medication than in patients not taking supplements. The level of ionized calcium was the strongest factor determining lumbar spine BMD in patients not receiving Calcium-D3 supplementation. Pregnancy ending in childbirth and HDL-cholesterol were associated with a weak adverse effect on spine and femoral BMD. No evidence of adverse effects of L-T4 and of radioiodine therapies on BMD was found. We conclude that Calcium-D3 medication has a beneficial effect on BMD, and that TSH-suppressive therapy does not affect BMD in women treated for DTC at young age, at least after 10 years of follow-up.

著者

Jun Miyata Hirotomo Yamanashi Shin-Ya Kawashiri Sakiko Soutome Kazuhiko Arima Mami Tamai Fumiaki Nonaka Yukiko Honda Masayasu Kitamura Koji Yoshida Yuji Shimizu Naomi Hayashida Shigeru Kawakami Noboru Takamura Takashi Sawase Atsutoshi Yoshimura Yasuhiro Nagata Mayumi Ohnishi Kiyoshi Aoyagi Atsushi Kawakami Toshiyuki Saito Takahiro Maeda

出版者

Japan Epidemiological Association

雑誌

Journal of Epidemiology (ISSN:09175040)

巻号頁・発行日

pp.JE20230079, (Released:2023-07-29)

参考文献数

42

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In an aging society, it is important to visualize the conditions of people living with diseases or disabilities, such as frailty and sarcopenia, and determine the environmental and genetic factors underlying such conditions. Atherosclerosis and arterial stiffness are key conditions between these factors and noncommunicable diseases. In 2014, we launched a population-based prospective open-cohort study, the Nagasaki Islands Study (NaIS), which was conducted in Goto City, located in the remote islands of Nagasaki Prefecture, Japan, mostly involving middle-aged and older residents. We conducted our own health checkups along with the annual standardized checkups organized by the municipality; recruited study participants; and started to follow-up with them for vital status (death), migration, and occurrence of diseases such as myocardial infarction, stroke, fracture, and human T-cell leukemia virus type 1 (HTLV-1) -associated uveitis. Our checkups were conducted as baseline surveys in different areas of Goto City during the fiscal years 2014–2016, secondary surveys during 2017–2019, and tertiary surveys since 2021, consisting of medical interviews, physical examinations, blood and urine tests, body composition measurements, osteoporosis screening, arterial stiffness measurements, carotid ultrasonography, and dental examination. A total of 4,957 residents participated in either the baseline or secondary surveys and were followed-up; and 3,594 and 3,364 residents (aged 27–96 and 28–98 years) participated in the baseline and secondary surveys, respectively. In conclusion, the NaIS has been undertaken to reveal the influence of aging and risk factors of noncommunicable diseases and disabilities, with an aim to contribute towards better healthcare in the future.

著者

Juan Luis UGARTE CABO Hideki FUKUDA Yasuyo ABE Noboru TAKAMURA Makoto OSAKI Zhaojia YE Yumiko KAWASHITA Keiko HONDA Kohei INADA Yuko KOBUKE Fumiaki SHINSHO Kiyoshi AOYAGI

出版者

Nagasaki University School of Medicine

雑誌

Acta Medica Nagasakiensia (ISSN:00016055)

巻号頁・発行日

vol.51, no.3, pp.89-94, 2006 (Released:2006-11-22)

参考文献数

32

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Good oral health is considered essential in maintaining of individual's good overall health. Information on oral problems and the behavior in visiting dentist is important for promoting oral health of the elderly. To elucidate the oral health status of the elderly in rural areas and factors affecting their oral health, we studied 147 people aged 60 years or over in a rural area of Nagasaki prefecture, Japan. We examined the dental status (dentate or edentate) and denture adaptability, and collected the information on socio-demographic variables, habits, chewing ability, visit to dentist for oral problems, self-perceived general health, and self-perceived oral health. About one-third of the subjects (47/147) had poor self-perceived oral health. Most socio-demographic variables were not associated with poor self-perceived oral health. Logistic regression analysis showed that poor chewing ability (odds ratio (OR): 3.4; 95% confidence interval (CI): 1.4-8.7), being dentate (OR: 6.6, 95% CI: 2.2-24.0), inadequate denture adaptability (OR: 3.7; 95% CI: 1.7-8.8), and no visit to dentist for oral problems (OR: 4.8; 95% CI: 1.8-14.2) were significantly associated with poor self-perceived oral health. In rural areas in Japan, adequate dental care and its good accessibility would be important for promoting the oral health in the elderly.

著者

Zhaojia Ye Yasuyo Abe Yosuke Kusano Noboru Takamura Kazuyuki Eida Tai-ichiro Takemoto Kiyoshi Aoyagi

出版者

Japan Society of Physiological Anthropology

雑誌

Journal of PHYSIOLOGICAL ANTHROPOLOGY (ISSN:18806791)

巻号頁・発行日

vol.26, no.2, pp.69-73, 2007 (Released:2007-04-15)

参考文献数

24

被引用文献数

34 47

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Visual display terminals (VDT) are standard equipment for many office workers. Their use, however, may increase the risk of developing adverse conditions related to vision, the musculoskeletal system, and mental health. We carried out a survey among 3070 workers aged 18 to 67 years (mean, 39.9 years) at a prefectural administrative office, in which 76% of subjects were visual display terminal (VDT) users. We examined the relationship between duration of daily VDT use and eyestrain, neck or upper extremity pain, back pain, and mental health, and estimated the effect of breaks and rest during VDT work on these symptoms. The 12-item General Health Questionnaire (GHQ-12: total scores ranged from 0 to 12) was used to identify potential poor mental health status, and subjects with 4 or more were considered to have symptoms of psychological distress. Seventeen percent of subjects reported eyestrain, 19.1% reported upper extremity pain, 11.6% reported back pain, and 17% of subjects had GHQ-12 scores of 4 or higher. Logistic regression analysis showed that duration of daily VDT use and lack of breaks and rest during VDT work were significantly associated with eyestrain, neck or upper extremity pain, back pain, and psychological distress. In order to protect users from the adverse effects associated with VDT work, reducing daily VDT exposure, taking breaks, and rest during VDT work are important.

著者

Noboru TAKAMURA Shunichi YAMASHITA

出版者

Nagasaki University School of Medicine

雑誌

Acta Medica Nagasakiensia (ISSN:00016055)

巻号頁・発行日

vol.50, no.Supplement1, pp.S11-S13, 2005 (Released:2006-03-20)

参考文献数

12

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For many years, Nagasaki University, particularly the Atomic Bomb Disease Institute, has been engaged in research regarding the late health effects of radiation exposure in Nagasaki atomic bomb survivors. Since 1991, we have participated in several Chernobyl projects including the Chernobyl Sasakawa Medical Cooperation Project which demonstrated a marked increase in the incidence of childhood thyroid cancer around Chernobyl, especially in the Gomel region, Belarus. Furthermore, we have performed both fieldwork and research to clarify the late effects of radiation exposure around Semipalatinsk Nuclear Testing Site and participated in bilateral official medical assistance projects between Japan and Kazakhstan to strengthen the medical infrastructure in this area. Through these humanitarian and scientific projects, we have been collaborating closely with our counterparts in the former USSR for the past 15 years. Here, we present a brief review of our past activities and future directions of international cooperative radiation research from Nagasaki to Chernobyl and Semipalatinsk.

著者

Yasuyuki TAIRA Naomi HAYASHIDA Sergey ZHAVARANAK Alexander KOZLOVSKY Anatoly LYZIKOV Shunichi YAMASHITA Noboru TAKAMURA

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

vol.56, no.2, pp.257-261, 2009 (Released:2009-04-29)

参考文献数

26

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In 2007, we screened urinary iodine (UI) concentrations in urban (Gomel city) and in rural areas (Hoiniki city) of the Gomel Region, Republic of Belarus, which was heavily contaminated by the accident at the Chernobyl Nuclear Power Plant, in order to evaluate the current state of iodine supplementation in these areas. Median levels of UI were 220.5 μg/L (151.5-358.5) μg/L in Gomel city, and 228.0 μg/L (130.0-337.5) μg/L in Hoiniki city. Urinary concentrations in Gomel city were significantly improved, as compared to our previous results in 2000 (p<0.001). There were no differences of UI concentrations between Gomel city and Hoiniki city (p = 0.39), and none of the samples showed moderate (<50 μg/L) or severe (<20 μg/L) iodine deficiency in either city. These results suggest that the state of iodine supplementation has improved in rural areas, as well as in urban areas in the Republic of Belarus, probably due to appropriate fortification of iodized salt in this region.

著者

Yasuyuki TAIRA Naomi HAYASHIDA Gopalganapathi M. BRAHMANANDHAN Yuji NAGAYAMA Shunichi YAMASHITA Jumpei TAKAHASHI Alexander GUTEVITC Alexander KAZLOVSKY Marat URAZALIN Noboru TAKAMURA

出版者

Journal of Radiation Research Editorial Committee

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.52, no.1, pp.88-95, 2011 (Released:2011-01-29)

参考文献数

24

被引用文献数

25

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To evaluate current environmental contamination and contributions from internal and external exposure due to the accident at the Chernobyl Nuclear Power Plant (CNPP) and nuclear tests at the Semipalatinsk Nuclear Testing Site (SNTS), concentrations of artificial radionuclides in edible mushrooms, soils and stones from each area were analyzed by gamma spectrometry. Annual effective doses were calculated for each area from the cesium contamination. Calculated internal effective doses of 137Cs due to ingestion of mushrooms were 1.8 × 10–1 mSv/year (y) in Gomel city (around CNPP), 1.7 × 10–1 mSv/y in Korosten city (around CNPP), 2.8 × 10–4 mSv/y in Semipalatinsk city, and 1.3 × 10–4 mSv/y in Nagasaki. Calculated external effective doses of 137Cs were 3.4 × 10–2 mSv/y in Gomel city, 6.2 × 10–2 mSv/y in Korosten city, 2.0 × 10–4 mSv/y in Semipalatinsk city, and 1.3 × 10–4 mSv/y in Nagasaki. Distribution of radionuclides in stones collected beside Lake Balapan (in SNTS) were 241Am (49.4 ± 1.4 Bq/kg), 137Cs (406.3 ± 1.7 Bq/kg), 58Co (3.2 ± 0.5 Bq/kg), and 60Co (125.9 ± 1.1 and 126.1 ± 1.1 Bq/kg). The present study revealed that dose rates from internal and external exposure around CNPP were not sufficiently low and radiation exposure potency still exists even though current levels are below the public dose limit of 1 mSv/y (ICRP1991). Moreover, parts of the SNTS area may be still contaminated by artificial radionuclides derived from nuclear tests. Long-term follow-up of environmental monitoring around CNPP and SNTS, as well as evaluation of health effects in the population residing around these areas, may contribute to radiation safety with a reduction of unnecessary exposure of residents.

著者

Noboru TAKAMURA Yoshihiro NAKAMURA Katsu ISHIGAKI Jitsuro ISHIGAKI Mariko MINE Kiyoshi AOYAGI Shunichi YAMASHITA

出版者

Journal of Radiation Research Editorial Committee

雑誌

Journal of Radiation Research (ISSN:04493060)

巻号頁・発行日

vol.45, no.2, pp.201-204, 2004 (Released:2004-08-10)

参考文献数

16

被引用文献数

11

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We examined the effect of stable iodine on thyroid gland blockade in patients with hyperthyroidism in order to make a preliminary evaluation of the appropriate dose of iodine prophylaxis in the event of a radiation emergency in Japan in which radioiodine is released to the environment. Eight patients were orally given single doses of 50 mg or 100 mg of potassium iodide, which contained 38 mg and 76 mg of iodide, respectively. Both doses significantly suppressed a thyroid uptake of 123I for 24 h (p = 0.03). The protective effects at 24 h were 73.3% and 79.5%, respectively. No side effects were observed during the trial. The present study demonstrates that a single oral administration of 38 mg of iodide produces a thyroid-blocking effect equivalent to that of 76 mg of iodide, suggesting that a reevaluation of the stable iodine dosage during radiation emergencies in iodine-rich areas such as Japan is warranted.