著者

Zhichao Ma Jie Qi Li Gao Jun Zhang

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

vol.61, no.5, pp.1022-1033, 2020-09-29 (Released:2020-09-29)

参考文献数

41

被引用文献数

7

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Cardiac hypertrophy is one of the significant risk factors that result in maladaptive cardiac remodeling and heart failure, and exercise is known to exert cardioprotection. In this research, the cardioprotective function and exercise mechanisms were explored.The rats underwent transverse aortic constriction (TAC) or a sham operation. The rats that received TAC were randomly assigned to five groups: (1) rats subjected to a sham operation as control group (SC), (2) rats that underwent TAC group (TC), (3) TAC and moderate-intensity exercise group (TE), (4) TE plus 3-MA group (TEM), and (5) TE plus Compound C group (TEC). The heart function was measured via echocardiography. Histological analysis and relative protein testing were conducted to analyze collagen deposition and apoptosis. Furthermore, western blot was employed to measure the protein expression of relevant signaling pathways. Impaired cardiac function, interstitial fibrosis, enhanced apoptosis, and ER stress were observed in the TAC-induced left ventricular hypertrophy. Exercise attenuated TAC-induced cardiac dysfunction, interstitial fibrosis, and ER stress-related apoptosis. In addition, exercise significantly improved autophagy and upregulated AMPK phosphorylation. Furthermore, AMPK inhibitor Compound C repressed the activation of AMPK, and autophagy inhibitor 3-methyladenine reversed exercise-induced autophagy. All of these abolished the protection of exercise against cardiac dysfunction and fibrosis induced by TAC.Our results indicated that 4 weeks of treadmill exercise could alleviate pressure overload-induced LV dysfunction and remodeling via an autophagy-dependent mechanism, which was induced by enhancing autophagy through the activation of AMPK.

著者

植木 武 石橋 義永 吉野 諒三 トークゥオーティ ジュリア タマシロ ロイ エドモンドソン ロバート 張 正軍 Takeshi Ueki Yoshinaga Ishibashi Ryozo Yoshino Julia Torquati Roy Tamashiro Robert Edmondson Zheng jun Zhang

雑誌

共立女子大学・共立女子短期大学総合文化研究所紀要 = Bulletin of Center for Interdisciplinary Studies of Science and Culture, Kyoritsu Women's University & Junior College

巻号頁・発行日

vol.22, pp.15-46,(1)-(7), 2016-02