著者
Okada Masako Hoang Hai Tamori Akihiro Uchida-Kobayashi Sawako Enomoto Masaru Kumada Hiromitsu Kawada Norifumi
出版者
Springer
雑誌
Clinical Journal of Gastroenterology (ISSN:18657265)
巻号頁・発行日
vol.12, no.3, pp.213-217, 2018-11-16

There have been a few reports on the treatment of patients infected with recombinant hepatitis C virus (HCV) genotype 2/1 strains with direct acting antivirals (DAAs). We experienced three patients with genotype 2/1 recombinant HCV, treated with DAAs successfully. The first, a 39-year-old man, was infected with recombinant HCV genotype 2a/1b, a rare variant....
著者
KIDA Yujiro ASAHINA Kinji INOUE Kouji KAWADA Norifumi YOSHIZATO Katsutoshi WAKE Kenjiro SATO Tetsuji
出版者
International Society of Histology and Cytology
雑誌
Archives of histology and cytology (ISSN:09149465)
巻号頁・発行日
vol.70, no.2, pp.95-106, 2007-06-30
被引用文献数
10

The expression of the cytoglobin/stellate cell activation-associated protein (Cygb/STAP) was recently confirmed in all splanchnic vitamin A-storing cells - including hepatic stellate cells (HSCs) - in normal conditions. In the hepatic fibrous lesion, the expression of Cygb/STAP has been shown to be upregulated in activated HSCs and myofibroblasts (MFs), which have synthesized extracellular matrices. Furthermore, splanchnic vitamin A-storing cells have been reported to be distributed in the kidney. In this study, we clarify the contribution of vitamin A-storing cells to renal fibrosis by focusing on Cygb/ STAP. Adult mice were subjected to unilateral ureteral obstruction (UUO) and kidneys were harvested 1, 3, 7, and 10 days after UUO.<BR> Numbers of Cygb/STAP-immunopositive cells as well as Cygb/STAP mRNA 3 days after UUO (UUO day 3 kidney) increased. Vitamin A-autofluorescence was observed in intertubular spaces of controls but gradually declined in a time-dependent manner after UUO. Cygb/STAP<SUP>+</SUP> cells were not completely identical with α-smooth muscle actin (αSMA)-positive cells in the control or UUO day 7 kidneys. Immunohistochemical analysis for Cygb/STAP and fibulin-2 (Fib), a specific marker for distinguishing MFs from activated HSCs, revealed that the number of Fib<SUP>+</SUP>STAP<SUP>+</SUP> cells (MFs) and Fib-STAP<SUP>+</SUP> cells (splanchnic vitamin A-storing cells) significantly increased in UUO day 3 and UUO day 7 kidneys compared with the controls. Our present findings support the concept that Cygb/STAP can be a unique marker for splanchnic fibroblast-like cells, namely the vitamin A-storing cell lineage, and suggest that splanchnic vitamin A-storing cells contribute to renal fibrogenesis in the obstructed kidney.