著者
TOSHIMITSU SHINGU TAKAHIRO UCHIDA MASUJI NISHI KAZUO HAYASHIDA SEIZABURO KASHIWAGI JUN HAYASHI MASARO KAJI
出版者
Kurume University School of Medicine
雑誌
The Kurume Medical Journal (ISSN:00235679)
巻号頁・発行日
vol.29, no.3, pp.123-125, 1983-04-15 (Released:2010-02-08)
参考文献数
3
被引用文献数
9 16

Seventeen hospital employees were inoculated with 40 -μcg hepatitis B vaccine as a part of a phase 1 trial in Japan. More than 90 per cent of the subjects developed antibodies against HBsAg after two doses of the vaccine. The third dose had a booster effect. Seven of the 16 vaccinated women experienced menstrual abnormalities after the first and/or second inoculation. These included hypomenorrhea, too short menstruation, oligomenorrhea and polymenorrhea. One subject also suffered from acne after the third inoculation. These abnormalities may be side effects of the hepatitis B vaccine which have not been reported previously.