著者

TOSHIMITSU SHINGU TAKAHIRO UCHIDA MASUJI NISHI KAZUO HAYASHIDA SEIZABURO KASHIWAGI JUN HAYASHI MASARO KAJI

出版者

Kurume University School of Medicine

雑誌

The Kurume Medical Journal (ISSN:00235679)

巻号頁・発行日

vol.29, no.3, pp.123-125, 1983-04-15 (Released:2010-02-08)

参考文献数

3

被引用文献数

9 16

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Seventeen hospital employees were inoculated with 40 -μcg hepatitis B vaccine as a part of a phase 1 trial in Japan. More than 90 per cent of the subjects developed antibodies against HBsAg after two doses of the vaccine. The third dose had a booster effect. Seven of the 16 vaccinated women experienced menstrual abnormalities after the first and/or second inoculation. These included hypomenorrhea, too short menstruation, oligomenorrhea and polymenorrhea. One subject also suffered from acne after the third inoculation. These abnormalities may be side effects of the hepatitis B vaccine which have not been reported previously.