A new antibiotic, funiculosin, C27H41NO7, was isolated from the filter cake of the fermented broth of Penicillium funiculosum THOM. Funiculosin is a neutral lipophilic substance which inhibits both DNA and RNA viruses as tested in infected primary chick embryo fibroblast cell monolayer and also some pathogenic fungi such as Tricophyton mentagrophytes and Candida albicans.
A new antibiotic, oryzachlorin, C26H31O8N2S2Cl(λmax 298mμ in ethanol) has been isolated from Aspergillus oryzae. It strongly inhibits the growth of many yeasts but has no effect on bacteria or filamentous fungi. It also has antiviral activity in vitro.