- 著者
- KUNIO ANDO SEIKICHI SUZUKI TETSUJI SAEKI GAKUZO TAMURA KEI ARIMA
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.22, no.5, pp.189-194, 1969-05-25 (Released:2006-04-12)
- 参考文献数
- 11
- 被引用文献数
- 31 36
A new antibiotic, funiculosin, C27H41NO7, was isolated from the filter cake of the fermented broth of Penicillium funiculosum THOM. Funiculosin is a neutral lipophilic substance which inhibits both DNA and RNA viruses as tested in infected primary chick embryo fibroblast cell monolayer and also some pathogenic fungi such as Tricophyton mentagrophytes and Candida albicans.
1 0 0 0 OA ORYZACHLORIN, A NEW ANTIFUNGAL ANTIBIOTIC
- 著者
- AKIKO KATO TETSUJI SAEKI SEIKICHI SUZUKI KUNIO ANDO GAKUZO TAMURA KEI ARIMA
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.22, no.7, pp.322-326, 1969-07-25 (Released:2006-04-12)
- 参考文献数
- 4
- 被引用文献数
- 16 19
A new antibiotic, oryzachlorin, C26H31O8N2S2Cl(λmax 298mμ in ethanol) has been isolated from Aspergillus oryzae. It strongly inhibits the growth of many yeasts but has no effect on bacteria or filamentous fungi. It also has antiviral activity in vitro.
- 著者
- GAKUZO TAMURA KUNIO ANDO SEIKICHI SUZUKI AKIRA TAKATSUKI KEI ARIMA
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.21, no.2, pp.160-161, 1968-02-25 (Released:2006-04-12)
- 参考文献数
- 5
- 被引用文献数
- 92 95
- 著者
- Teiichiro ITO Akira TAKATSUKI Kenji KAWAMURA Katsuki SATO Gakuzo TAMURA
- 出版者
- Japan Society for Bioscience, Biotechnology, and Agrochemistry
- 雑誌
- Agricultural and Biological Chemistry (ISSN:00021369)
- 巻号頁・発行日
- vol.44, no.3, pp.695-698, 1980 (Released:2008-11-27)
- 参考文献数
- 11
- 被引用文献数
- 44
- 著者
- Junji MAGAE Kazuo NAGAI Kunio ANDO Gakuzo TAMURA
- 出版者
- Japan Society for Bioscience, Biotechnology, and Agrochemistry
- 雑誌
- Agricultural and Biological Chemistry (ISSN:00021369)
- 巻号頁・発行日
- vol.52, no.12, pp.3143-3147, 1988 (Released:2006-04-05)
- 参考文献数
- 12
- 被引用文献数
- 9 1
Mouse myeloid leukemia cells, Ml, were induced to differentiate into phagocytes by treatment with ascofuranone (AF). AF also induced differentiation of human promyelocytic leukemia HL60 cells and human erythroid leukemia K562 cells into granulocytes and erythrocytes, as detected by nitroblue tetrazolium reducing activity and benzidine staining, respectively. The antibiotic enhanced acetate incorporation of K562 cells. The increase was not observed with the cells of HL60 and two human B lymphoma lines, Daudi and Raji. The increase was diminished by the addition of a glycolysis inhibitor, deoxyglucose. Inhibitors of respiration, antimycin and sodium azide, also enhanced acetate incorporation of K562 cells specifically, which was diminished by the addition of deoxyglucose. Furthermore, antimycin induced differentiation of K562 and HL60 cells. These results suggest a possible relationship between cell differentiation and inhibition of respiration.
1 0 0 0 OA ANTITUMOR AND ANTIMETASTATIC ACTIVITY OF AN ANTIBIOTIC, ASCOFURANONE, AND ACTIVATION OF PHAGOCYTES
- 著者
- JUNJI MAGAE JUNICHI HAYASAKI YUKO MATSUDA MITSUYUKI HOTTA TOMOYOSHI HOSOKAWA SEIKICHI SUZUKI KAZUO NAGAI KUNIO ANDO GAKUZO TAMURA
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.41, no.7, pp.959-965, 1988-07-25 (Released:2006-04-19)
- 参考文献数
- 20
- 被引用文献数
- 34 41
Ascofuranone demonstrated antitumor activity against FM3A murine mammary carcinoma, implanted in the peritoneal cavity of syngeneic mice, C3H/He. It was more effective by treatment prior to implantation than by that after implantation. Treatment with ascofuranone also increased splenic cytotoxicity and phagocytic activity of host animal cells. Moreover, ascofuranone induced inflammatory cells in the peritoneal cavity which are mainly composed of polymorpho-nuclear leukocytes and macrophages. These cells are more potent in cytotoxicity against FM3A cells than with resident peritoneal cells. The antitumor activity of ascofuranone was suppressed by ip administration of silica, just prior to tumor implantation. These results suggest that the prophylactic antitumor activity of ascofuranone is expressed through the activation of phagocytes. Ascofuranone also suppressed pulmonary metastasis of B16 melanoma and Lewis lung carcinoma. Treatment after tumor implantaion failed to suppress the metastasis. Single treatment of ascofuranone 4 days prior to implantation decreased the metastasis of Lewis lung carcinoma but not that of B16, whereas single treatment of ascofuranone 24 hours prior to the tumor implantation decreased the metastasis of B16 but not that of Lewis lung carcinoma.