著者
佐藤 勝明 Katsuaki SATO
出版者
和洋女子大学
雑誌
和洋女子大学紀要 = The journal of Wayo Women's University (ISSN:18846351)
巻号頁・発行日
no.62, pp.201-212, 2021-03-31

蕉風以外の未注釈の連句作品を分析する第二弾として、無倫編『俳諧紙文夾』(元禄十年秋序)に収められる、嵐雪・無倫・艶士・止水による四吟歌仙を対象とする。そして、その分析により、嵐雪と無倫らの間に不協和音は感じられず、芭蕉流の付け方が共有されていると見られるものの、各付合では詞の連想に頼った側面もあり、一巻全体では変化を重んじる意識が希薄であることを指摘する。
著者
Takamichi Yamamoto Seung Bong Hong Masahiro Shimizu Katsuaki Sato Yotaro Numachi
出版者
日本てんかん学会
雑誌
Epilepsy & Seizure (ISSN:18825567)
巻号頁・発行日
vol.7, no.1, pp.55-65, 2014-08-15 (Released:2014-08-15)
参考文献数
12
被引用文献数
5

Purpose: To evaluate the efficacy and safety of lamotrigine monotherapy in patients with newly diagnosed partial seizures including secondarily generalized seizures or generalized tonic-clonic seizures, and those with recurrent seizures in Japan and South Korea.Methods: The study was a multi-center, open-label, evaluation of lamotrigine monotherapy in patients with newly diagnosed epilepsy or epilepsy with recurrent seizures. The primary endpoint was the seizure-free rate in the maintenance phase.Results: A total of 67 patients were enrolled; 52 patients completed 6 weeks of treatment (the escalation phase) and 42 patients completed 30 weeks of treatment (the escalation phase and the maintenance phase). The seizure-free rate in the maintenance phase for all seizure types was 43.1%. Adverse events (AEs) were reported in 82% (53/65) of patients. The most common AEs were headache (14/65, 22%), nasopharyngitis (12/65, 18%) and rash (7/65, 11%).Conclusion: The seizure-free rate with lamotrigine monotherapy in the maintenance phase was 43.1% for all seizure types. Lamotrigine monotherapy appears to be effective in patients with newly diagnosed epilepsy and those with recurrent seizures in Japan and South Korea. The safety profile of lamotrigine in this monotherapy study was similar to that observed in patients with adult bipolar disorder treated with lamotrigine monotherapy.