著者

Takao Sugiura Naoko Ito Katsumasa Goto Hisashi Naito Toshitada Yoshioka Scott K. Powers

出版者

PHYSIOLOGICAL SOCIETY OF JAPAN

雑誌

The Journal of Physiological Sciences (ISSN:18806546)

巻号頁・発行日

vol.56, no.6, pp.393-399, 2006 (Released:2006-12-28)

参考文献数

43

被引用文献数

34 37

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We tested the hypothesis that estrogen administration would retard immobilization-induced muscle atrophy in adult male rats. The rats were injected for 24 days with either estrogen (40 μg/kg−1, β-estradiol 3-benzoate in olive oil vehicle), or vehicle alone. At day 14 of estrogen treatment, the hindlimb muscles of one leg were immobilized in plantar flexion position by the use of a plaster cast. Following 10 days of immobilzation, the atrophic and the contralateral soleus muscles were both removed and analyzed to determine the level of muscle atrophy along with the measurement of the protein levels of Cu-Zn-superoxide dismutase (Cu-Zn-SOD), heat shock protein 72 (HSP72), and selected proteases. Compared to placebo animals, estrogen treatment significantly reduced (–35%) muscle atrophy. Further, estrogen significantly abridged the expression of the calcium-activated protease, calpain, in the atrophied hindlimb muscle. In contrast, estrogen treatment did not alter the protein levels of HSP72 in the immobilized soleus muscle. These results support the postulate that estrogen attenuates the rate of disuse muscle atrophy, partly because of reductions in immobilization-induced calcium-activated protease levels.

著者

Hiroto Fujiya Katsumasa Goto

出版者

The Japanese Society of Physical Fitness and Sports Medicine

雑誌

The Journal of Physical Fitness and Sports Medicine (ISSN:21868131)

巻号頁・発行日

vol.5, no.1, pp.69-72, 2016-03-25 (Released:2016-03-18)

参考文献数

26

被引用文献数

2 4

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Sports-associated injuries often involve trauma to soft tissues such as ligaments, tendons, skeletal muscle, and skin. A shortened recovery process for injured tissues is of great interest to athletes, as injury-associated inactivity depresses both sports performance and physical fitness. Recently proposed treatments to accelerate tissue repair include microcurrent electrical neuromuscular stimulation (MENS), low-intensity pulsed ultrasound (LIPUS), hyperbaric oxygen (HBO), and autologous platelet-rich plasma (PRP). Among these treatments, MENS has been applied to alleviate pain and reduce swelling following sports-associated injuries of tendons and ligaments. MENS is reported to stimulate the regeneration of skeletal muscles, a part of the body commonly injured in sports. MENS is expected to soon become a standard therapy for accelerating the repair of injured skeletal muscles and other soft tissues. In this review, we provide an overview of MENS and briefly describe several other proposed treatments for sports-associated injuries.