著者

西村 和雄 ニシムラ カズオ Kazuo Nishimura

雑誌

東京情報大学研究論集

巻号頁・発行日

vol.2, no.3, pp.147-168, 1999-03

著者

西村 和雄 Kazuo Nishimura

雑誌

エコノフォーラム21 : 学生と教職員のインターコミュニケーション誌 = Econo forum 21

巻号頁・発行日

no.23, pp.8-10, 2017-03-16 (Released:2017-12-06)

著者

Midori Takada Taku Yasui Toru Oka Wataru Shioyama Tadashi Kuroda Yasutomo Nakai Kazuo Nishimura Mikio Mukai Masashi Fujita

出版者

International Heart Journal Association

雑誌

International Heart Journal (ISSN:13492365)

巻号頁・発行日

pp.17-461, (Released:2018-08-29)

参考文献数

29

被引用文献数

22

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Angiogenesis inhibitors, such as sorafenib and axitinib, which target vascular endothelial growth factor (VEGF) signaling, are widely used for renal cell carcinoma, including metastasis. In this study, we report a case of cardiovascular adverse events of aortic dissection and cardiac dysfunction during treatment with sorafenib and axitinib for metastatic renal cell carcinoma. A 66-year-old man had been administered sorafenib for 2 years after nephrectomy due to renal cell carcinoma. To control the progression of metastatic lung tumor, axitinib was started after sorafenib for four years. During the treatment, angiotensin II type 1 receptor blockers and Ca antagonists were used to strictly control the axitinib-induced hypertension and proteinuria. Aortic dissection and cardiac dysfunction occurred coincidentally. Considering the critical role of VEGF signaling in the homeostasis of the cardiovascular system, we speculated that the long-term use of axitinib and sorafenib directly influenced the initiation of aortic dissection and cardiac dysfunction. Although the precise mechanisms underlying the aortic dissection and cardiac dysfunction induced by angiogenesis inhibition are still elusive, onco-cardiologists and oncologists should pay careful attention to cardiovascular toxicity and complications in patients with cancer, particularly patients undergoing long-term cancer treatment.