著者

Kei Sawada Shigehiro Karashima Mitsuhiro Kometani Rie Oka Yoshimichi Takeda Toshitaka Sawamura Aya Fujimoto Masashi Demura Ayako Wakayama Mikiya Usukura Kunimasa Yagi Yoshiyu Takeda Takashi Yoneda

出版者

The Japan Endocrine Society

雑誌

Endocrine Journal (ISSN:09188959)

巻号頁・発行日

pp.EJ17-0440, (Released:2018-02-20)

被引用文献数

27

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Obstructive sleep apnea syndrome (OSAS) is often associated with metabolic disorders such as obesity and type 2 diabetes and may contribute to cardiovascular events. A novel class of antidiabetic drugs, the sodium glucose cotransporter 2 inhibitors (SGLT2i) reduce body weight (BW), although there is limited data on their impact on OSAS. We therefore evaluated the effect of SGLT2i on OSAS in patients with type 2 diabetes. The presented study was a retrospective design in 18 patients with type 2 diabetes with OSAS (4 males, age range 39–81 yr) administrated a SGLT2i. HbA1c, BW, body mass index (BMI), blood pressure (BP) and apnea hypopnea index (AHI) were evaluated before and after SGLT2i administration. The relationships between the reduction in AHI and the other variables were examined using Pearson correlation analysis. We have got result that SGLT2i reduced AHI from 31.9 ± 18.0 to 18.8 ± 11.5 events per hr (p = 0.003). HbA1c, BW and BMI decreased significantly, whereas BP did not. The Pearson correlation analysis showed a significant relationship between the reduction in AHI and pre-administration of AHI. In conclusion, SGLT2i reduced not only HbA1c, BW and BMI but also AHI significantly and therefore has potential as an effective treatment of OSAS.

著者

Kei Sawada Kei Hashimoto Keiichiro Oura Yoshihiko Nankaku Keiichi Tokuda

出版者

ACOUSTICAL SOCIETY OF JAPAN

雑誌

Acoustical Science and Technology (ISSN:13463969)

巻号頁・発行日

vol.39, no.2, pp.119-129, 2018-03-01 (Released:2018-03-01)

参考文献数

35

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This paper proposes a method for constructing text-to-speech (TTS) systems for languages with unknown pronunciations. One goal of speech synthesis research is to establish a framework that can be used to construct TTS systems for any written language. Generally, language-specific knowledge is required to construct TTS systems for a new language. However, it is difficult to acquire language-specific knowledge in each new language. Therefore, constructing a TTS system for a new language entails huge costs. To address this problem, we investigate a framework for automatically constructing a TTS system from a target language database consisting of only speech data and corresponding Unicode texts. In the proposed method, pseudo phonetic information of the target language with unknown pronunciation is obtained by a speech recognizer of a rich-resource proxy language. Then, a grapheme-to-phoneme converter and a statistical parametric speech synthesizer are constructed based on the obtained pseudo phonetic information. The proposed method was applied to Japanese and was evaluated in terms of objective and subjective measures. Additionally, we challenged the construction of TTS systems for nine Indian languages using the proposed method, and TTS systems were evaluated in the Blizzard Challenge 2014 and 2015.

著者

Kei SAWADA Akira TAMAMORI Kei HASHIMOTO Yoshihiko NANKAKU Keiichi TOKUDA

出版者

The Institute of Electronics, Information and Communication Engineers

雑誌

IEICE TRANSACTIONS on Information and Systems (ISSN:09168532)

巻号頁・発行日

vol.E99-D, no.12, pp.3119-3131, 2016-12-01

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This paper proposes a Bayesian approach to image recognition based on separable lattice hidden Markov models (SL-HMMs). The geometric variations of the object to be recognized, e.g., size, location, and rotation, are an essential problem in image recognition. SL-HMMs, which have been proposed to reduce the effect of geometric variations, can perform elastic matching both horizontally and vertically. This makes it possible to model not only invariances to the size and location of the object but also nonlinear warping in both dimensions. The maximum likelihood (ML) method has been used in training SL-HMMs. However, in some image recognition tasks, it is difficult to acquire sufficient training data, and the ML method suffers from the over-fitting problem when there is insufficient training data. This study aims to accurately estimate SL-HMMs using the maximum a posteriori (MAP) and variational Bayesian (VB) methods. The MAP and VB methods can utilize prior distributions representing useful prior information, and the VB method is expected to obtain high generalization ability by marginalization of model parameters. Furthermore, to overcome the local maximum problem in the MAP and VB methods, the deterministic annealing expectation maximization algorithm is applied for training SL-HMMs. Face recognition experiments performed on the XM2VTS database indicated that the proposed method offers significantly improved image recognition performance. Additionally, comparative experiment results showed that the proposed method was more robust to geometric variations than convolutional neural networks.