著者

Fumio YAGI Kenjiro TADERA

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Agricultural and Biological Chemistry (ISSN:00021369)

巻号頁・発行日

vol.51, no.6, pp.1719-1721, 1987 (Released:2006-04-05)

参考文献数

11

被引用文献数

9

著者

Kenjiro TADERA Yuji MINAMI Kouta TAKAMATSU Tomoko MATSUOKA

出版者

Center for Academic Publications Japan

雑誌

Journal of Nutritional Science and Vitaminology (ISSN:03014800)

巻号頁・発行日

vol.52, no.2, pp.149-153, 2006 (Released:2007-06-15)

参考文献数

15

被引用文献数

208 734

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The inhibitory activity of six groups of flavonoids against yeast and rat small intestinal α-glucosidases and porcine pancreatic α-amylase was compared, and chemical structures of flavonoids responsible for the inhibitory activity were evaluated. Yeast α-glucosidase was potently inhibited by the anthocyanidin, isoflavone and flavonol groups with the IC50 values less than 15 μM. The following structures enhanced the inhibitory activity: the unsaturated C ring, 3-OH, 4-CO, the linkage of the B ring at the 3 position, and the hydroxyl substitution on the B ring. Rat small intestinal α-glucosidase was weakly inhibited by many flavonoids, and slightly by the anthocyanidin and isoflavone groups. 3-OH and the hydroxyl substitution on the B ring increased the inhibitory activity. In porcine pancreatic α-amylase, luteolin, myricetin and quercetin were potent inhibitors with the IC50 values less than 500 μM. The 2, 3-double bond, 5-OH, the linkage of the B ring at the 3 position, and the hydroxyl substitution on the B ring enhanced the inhibitory activity, while 3-OH reduced it.