著者

小林 正規 奥平 修 千秋 博紀 和田 浩二 木村 宏 佐々木 晶 KOBAYASHI Masanori OKUDAIRA Osamu SENSHU Hiroki WADA Koji KIMURA Hiroshi SASAKI Sho

出版者

宇宙航空研究開発機構(JAXA)

雑誌

宇宙航空研究開発機構特別資料: 第17回「宇宙環境シンポジウム」講演論文集 = JAXA Special Publication: Proceedings of the 17th Spacecraft Environment Symposium (ISSN:24332232)

巻号頁・発行日

vol.JAXA-SP-20-007, pp.35-46, 2021-01-29

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第17回宇宙環境シンポジウム (2020年10月7日-8日. 宇宙航空研究開発機構(JAXA)オンライン会議)

著者

Kimura Hiroshi Fukagawa Misato Tamura Motohide KOBAYASHI Hiroshi YAMAMOTO Tetsuo ISHII Miki SUTO Hiroshi

出版者

Terra Scientific Pub. Co.

雑誌

Earth, planets and space (ISSN:13438832)

巻号頁・発行日

vol.62, no.1, pp.111-116, 2010-01-01

参考文献数

37

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We report near-infrared imaging observations of the β Pic dust disk, from which we infer the orbital architecture of planetesimal belts that remain near mean motion resonances (MMRs) with a planet at 62 AU. Our results reveal that one of the previously identified planetesimal belts lies in the 2/3 MMR with the planet, similar to the resonant relation between Plutinos and Neptune. We suggest that all the previously reported planetesimal belts are located near the 2/3 MMRs of four planets whose spatial arrangements make a similar figure of Jupiter, Saturn, Uranus, and Neptune. This implies that the Solar System is a prototype of planetary systems around main-sequence stars in terms of planets' configuration, as expected from planet formation theories.

著者

Hirose Tetsuro Virnicchi Giorgio Tanigawa Akie Naganuma Takao Li Ruohan Kimura Hiroshi Yokoi Takahide Nakagawa Shinichi Benard Marianne Fox Archa H. Pierron Gerard

出版者

Amer soc cell biology

雑誌

Molecular biology of the cell (ISSN:10591524)

巻号頁・発行日

vol.25, no.1, pp.169-183, 2014-01-01

被引用文献数

360

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Paraspeckles are subnuclear structures formed around nuclear paraspeckle assembly transcript 1 (NEAT1)/MEN epsilon/beta long noncoding RNA (IncRNA). Here we show that paraspeckles become dramatically enlarged after proteasome inhibition. This enlargement is mainly caused by NEAT1 transcriptional up-regulation rather than accumulation of undegraded paraspeckle proteins. Of interest, however, using immuno-electron microscopy, we find that key paraspeckle proteins become effectively depleted from the nucleoplasm by 50% when paraspeckle assembly is enhanced, suggesting a sequestration mechanism. We also perform microarrays from NEAT1-knockdown cells and find that NEAT1 represses transcription of several genes, including the RNA-specific adenosine deaminase B2 (ADARB2) gene. In contrast, the NEAT1-binding paraspeckle protein splicing factor proline/glutamine-rich (SFPQ) is required for ADARB2 transcription. This leads us to hypothesize that ADARB2 expression is controlled by NEAT1-dependent sequestration of SFPQ. Accordingly, we find that ADARB2 expression is strongly reduced upon enhanced SFPQ sequestration by proteasome inhibition, with concomitant reduction in SFPQ binding to the ADARB2 promoter. Finally, NEAT1(-/-) fibroblasts are more sensitive to proteasome inhibition, which triggers cell death, suggesting that paraspeckles/NEAT1 attenuates the cell death pathway. These data further confirm that paraspeckles are stress-responsive nuclear bodies and provide a model in which induced NEAT1 controls target gene transcription by protein sequestration into paraspeckles.