- 著者
- Tetsuya Konishi Kenichi Watanabe Somasundaram Arummugam Misato Sakurai Shinji Sato Seiichi Matsugoh Tetsuo Watanabe Koji Wakame
- 出版者
- Society for Glycative Stress Research
- 雑誌
- Glycative Stress Research (ISSN:21883602)
- 巻号頁・発行日
- vol.6, no.4, pp.248-257, 2019 (Released:2020-03-03)
- 著者
- Takehito MIURA Lan YUAN Buxiang SUN Hajime FUJII Mayumi YOSHIDA Koji WAKAME Ken-ichi KOSUNA
- 出版者
- (社)日本農芸化学会
- 雑誌
- Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)
- 巻号頁・発行日
- vol.66, no.12, pp.2626-2631, 2002 (Released:2003-06-25)
- 参考文献数
- 21
- 被引用文献数
- 80
Soybean extracts (SBE) containing isoflavone glycosides were cultured with Ganoderma lucidum mycelia producing β-glucosidase. The anti-angiogenic effects of the cultivated product, containing rich in genistein, named GCP (genistein combined polysaccharide), were assessed with chick chorioallantoic membranes (CAM) and a mouse dorsal air-sac model. β-Glucosidase produced by the mycelia converted the isoflavone glycosides into aglycons. A test of volunteers showed that serum concentrations of genistein in the subjects treated with GCP (n=4) at 3 h after administration were significantly higher than those in the subjects treated with SBE (n=4). GCP inhibited angiogenesis in CAM, and the activity of GCP was greater than that of SBE. GCP inhibited the formation of new vessels induced by colon carcinoma cells in vivo.