著者

渡辺 哲男 ワタナベ テツオ Tetsuo Watanabe

雑誌

立教大学教育学科研究年報

巻号頁・発行日

no.63, pp.103-126, 2020-02

著者

Tetsuya Konishi Kenichi Watanabe Somasundaram Arummugam Misato Sakurai Shinji Sato Seiichi Matsugoh Tetsuo Watanabe Koji Wakame

出版者

Society for Glycative Stress Research

雑誌

Glycative Stress Research (ISSN:21883602)

巻号頁・発行日

vol.6, no.4, pp.248-257, 2019 (Released:2020-03-03)

著者

渡辺 哲男 ワタナベ テツオ Tetsuo Watanabe

雑誌

立教大学教育学科研究年報

巻号頁・発行日

vol.63, pp.103-126, 2020-02

著者

渡辺 哲男 ワタナベ テツオ Tetsuo Watanabe

雑誌

立教大学教育学科研究年報

巻号頁・発行日

no.58, pp.83-93, 2015-02-28

著者

渡辺 哲男 ワタナベ テツオ Tetsuo Watanabe

雑誌

立教大学教育学科研究年報

巻号頁・発行日

no.57, pp.73-89, 2014-03-24

著者

Yutaka Nagata Tetsuo Watanabe Kazuhiko Nagasaka Masaaki Yamada Minoru Saito Toshinori Yazaki Kenichi Komatsu Mika Sano Koji Asano Chikao Ando Norihide Taniuchi

出版者

一般社団法人 日本内科学会

雑誌

Internal Medicine (ISSN:09182918)

巻号頁・発行日

vol.55, no.6, pp.573-581, 2016 (Released:2016-03-15)

参考文献数

22

被引用文献数

3 16

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Objective Mesenteric phlebosclerosis (MP) is a disease characterized by calcification of the mesenteric vein, which causes chronic mesenteric ischemia. Recently, the long-term intake of gardenia fruit ('Sanshishi' in Japanese) has been attracting attention as a possible cause. Usually, only advanced, severe MP cases get reported. However, we suspected that some latent cases of this disease may exist. We performed this study in order to determine the prediagnostic cases at our outpatient departments of herbal (Kampo) medicine, with particular attention paid to the initial changes, such as any slight color change of the colon, as shown in colonoscopy. Methods We recommend colonoscopy and computed tomography (CT) scans for patients with a long-term history of taking herbal medicines containing gardenia fruit. Clinical examinations were performed upon receiving patients' consent from December 2013 to November 2014. Results Of the 103 patients who took gardenia fruit long-term, 29 agreed to be checked for MP. 14 patients underwent colonoscopy. Four patients were confirmed to have MP due to the presence of fibrotic deposition of the colonic membrane on histological inspection. Twenty-one patients underwent abdominal CT screening. Characteristic calcification of the mesenteric vein was observed on CT scans in 2 patients. All 4 MP patients took Kampo formulas containing gardenia fruit for more than 6.8 years. The other patients did not develop MP, despite long-term gardenia fruit intake. Conclusion We detected the latent and undiagnosed MP cases. All diagnoses were made while paying careful attention to any slight changes in colonoscopy and CT scans.

著者

Tetsuo Watanabe Yuki Nakajima Tetsuya Konishi

出版者

公益社団法人日本薬学会

雑誌

Biological and Pharmaceutical Bulletin (ISSN:09186158)

巻号頁・発行日

vol.31, no.1, pp.111-117, 2008-01-01 (Released:2008-01-01)

参考文献数

40

被引用文献数

8 18

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Basidiomycetes-X (BDM-X) is a novel edible mushroom recently identified as a new fungi species and registered to the database of the NPO organization for International Patent Organism Depositing (IPOD) in the Industrial Technology Institute of Japan (PCT/JP2004/006418). In the present study, we examined anti-oxidant activity of hot water extract of this novel fungus both in vitro and in vivo together with Agaricus Blazei Murill (ABM), a commercially available medicinal mushroom, and other reference antioxidants. As results, the hot water extract of BDM-X showed more potent anti-oxidative actions compared with that of ABM, when evaluated by 1,1′-diphenyl-2-picrylhydrazyl (DPPH) scavenging activity, Ferric Reducing Potential (FRP), and also the inhibition of 2,2′-azobis(2-amidino-propane) dihydrochloride (AAPH)-induced lipid peroxidation of rat liver homogenates. Further, the protective activity of BDM-X extract towards lipopolysaccharide (LPS)-induced hepatic oxidative damage was compared with ABM and α-lipoic acid in the mice pre-administered with these antioxidants. It was revealed that all of these antioxidants inhibited the LPS-induced oxidative tissue damage but the hot water extract of BDM-X showed the strongest protection among them. For example, the dose for 50% inhibition of carbonyl formation in liver was 0.53 g dry weight/kg body weight/d for BDM-X and the value corresponded to 16 mmol of α-lipoic acid as an antioxidant reference/kg body weight/d.