著者
Shinji Sato Yoichi Kawanishi Masayuki Ide Noriko Sodeyama Hitoshi Takei
出版者
The Japanese Society of Clinical Neuropsychopharmacology
雑誌
Clinical Neuropsychopharmacology and Therapeutics (ISSN:18848826)
巻号頁・発行日
vol.10, pp.26-28, 2019-11-08 (Released:2019-11-08)
参考文献数
12
被引用文献数
1

Autism spectrum disorder (ASD) includes disturbances in communication, imagination, and social interaction. In individuals with ASD, selective mutism is a common symptom of a communication disability. Selective serotonin reuptake inhibitors (SSRIs) have been recommended to treat selective mutism, especially after psychosocial interventions fail. However, the mechanism and efficacy of SSRIs in treating selective mutism remain unclear. Here we report the case of an adult male with ASD whose selective mutism was improved by aripiprazole but not SSRIs. To the best of our knowledge, this is the first such case report. We believe that our patient's case highlights the value of differentiating between psychopathology and psychopharmacology when examining ASD symptoms.
著者
TOSHIHIKO TOKI NAOHIRO OIKAWA TORU TASE SHINJI SATO YUICHI WADA AKIRA YAJIMA HISASHI HIGASHIIWAI
出版者
Tohoku University Medical Press
雑誌
The Tohoku Journal of Experimental Medicine (ISSN:00408727)
巻号頁・発行日
vol.149, no.2, pp.163-167, 1986 (Released:2006-08-31)
参考文献数
12
被引用文献数
5 5

TOKI, T., OIKAWA, N., TASE, T., SATO, S., WADA, Y., YAJIMA, A. and HIGASHIIWAI, H. Immunohistochemical and Electron Microscopic Demonstration of Human Papillomavirus in Dysplasia of the Uterine Cervix. Tohoku J. exp. Med., 1986, 149 (2), 163-167 - Twenty-five cases of dysplasia of the uterine cervix were studied for the presence of human papillomavirus (HPV) by means of immunohistochemical and electron microscopic techniques. Serial sections of the same histological specimen were examined in each case. HPV was detected in 14 cases by both immunohistochemistry and electron microscopy, while 10 cases were negative with both methods. In only one case, there was a discrepancy in the results derived from these two methods. It was concluded that the relation between HPV infection and cervical dysplasia was confirmed and that immunohistochemical and electron microscopic methods led almost to the same result in detecting HPV in cervical dysplasia.