文献一覧: Kunio Kondo (著者)

8 0 0 0 OA Clinical Outcomes of Off-Label Dosing of Direct Oral Anticoagulant Therapy Among Japanese Patients With Atrial Fibrillation Identified From the SAKURA AF Registry

著者: Nobuhiro Murata Yasuo Okumura Katsuaki Yokoyama Naoya Matsumoto Eizo Tachibana Keiichiro Kuronuma Koji Oiwa Michiaki Matsumoto Toshiaki Kojima Shoji Hanada Kazumiki Nomoto Ken Arima Fumiyuki Takahashi Tomobumi Kotani Yukitoshi Ikeya Seiji Fukushima Satoru Itoh Kunio Kondo Masaaki Chiku Yasumi Ohno Motoyuki Onikura Atsushi Hirayama for the SAKURA AF Registry Investigators
出版者: The Japanese Circulation Society
雑誌: Circulation Journal (ISSN:13469843)
巻号頁・発行日: vol.83, no.4, pp.727-735, 2019-03-25 (Released:2019-03-25)
参考文献数: 27
被引用文献数: 61

Background: Off-label dosing of direct oral anticoagulants (DOACs) is encountered clinically among patients with atrial fibrillation (AF), although data on the clinical outcomes of over- and under-dosing are lacking in Japan. Methods and Results: We examined the clinical outcomes of off-label DOAC dosing using the SAKURA AF Registry, a prospective multicenter registry in Japan. Among 3,237 enrollees, 1,676 under any of the 4 DOAC regimens were followed up for a median of 39.3 months: 746 (45.0%), appropriate standard-dose; 477 (28.7%), appropriate low-dose; 66 (4.0%), over-dose; and 369 (22.2%) under-dose. Compared with the standard-dose group, patients in the under- and over-dose groups were significantly older and had a higher stroke risk. After multivariate adjustment, stroke/systemic embolism (SE) and death events were equivalent between the standard- and under-dose groups, but major bleeding events tended to be lower in the under-dose group (hazard ratio [HR] 0.474, P=0.0739). Composite events (stroke/SE, major bleeding, or death) were higher in the over-dose than in the standard-dose group (HR 2.714, P=0.0081). Conclusions: Clinical outcomes were not worse for under-dose than for standard-dose users among patients with different backgrounds. Over-dose users, however, were at higher risk for all clinical events and required careful follow-up. Further studies are needed to clarify the safety and effectiveness of off-label DOAC dosing in Japan.

2019-06-13 18:20:35
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4 0 0 0 OA Clinical Outcomes of Off-Label Dosing of Direct Oral Anticoagulant Therapy Among Japanese Patients With Atrial Fibrillation Identified From the SAKURA AF Registry

著者: Nobuhiro Murata Yasuo Okumura Katsuaki Yokoyama Naoya Matsumoto Eizo Tachibana Keiichiro Kuronuma Koji Oiwa Michiaki Matsumoto Toshiaki Kojima Shoji Hanada Kazumiki Nomoto Ken Arima Fumiyuki Takahashi Tomobumi Kotani Yukitoshi Ikeya Seiji Fukushima Satoru Itoh Kunio Kondo Masaaki Chiku Yasumi Ohno Motoyuki Onikura Atsushi Hirayama for the SAKURA AF Registry Investigators
出版者: The Japanese Circulation Society
雑誌: Circulation Journal (ISSN:13469843)
巻号頁・発行日: pp.CJ-18-0991, (Released:2019-02-05)
参考文献数: 27
被引用文献数: 61

2019-02-05 17:31:42
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2 0 0 0 OA Three-Year Clinical Outcomes Associated With Warfarin vs. Direct Oral Anticoagulant Use Among Japanese Patients With Atrial Fibrillation ― Findings From the SAKURA AF Registry ―

著者: Yasuo Okumura Katsuaki Yokoyama Naoya Matsumoto Eizo Tachibana Keiichiro Kuronuma Koji Oiwa Michiaki Matsumoto Toshiaki Kojima Shoji Hanada Kazumiki Nomoto Ken Arima Fumiyuki Takahashi Tomobumi Kotani Yukitoshi Ikeya Seiji Fukushima Satoru Itou Kunio Kondo Masaaki Chiku Yasumi Ohno Motoyuki Onikura Atsushi Hirayama for the SAKURA AF Registry Investigators
出版者: The Japanese Circulation Society
雑誌: Circulation Journal (ISSN:13469843)
巻号頁・発行日: vol.82, no.10, pp.2500-2509, 2018-09-25 (Released:2018-09-25)
参考文献数: 20
被引用文献数: 55

Background: Although direct oral anticoagulants (DOACs) are widely used in Japanese patients with atrial fibrillation (AF), large-scale investigations into their use, with suitable follow-up times and rates, are lacking. Methods and Results: The SAKURA AF Registry is a prospective multicenter registry created to investigate therapeutic outcomes of oral anticoagulant (OAC) use in Japanese AF patients. We conducted a study involving 3,237 enrollees from 63 institutions in the Tokyo area being treated with any of 4 DOACs (n=1,676) or warfarin (n=1,561) and followed-up for a median of 39.3 months (range 28.5–43.6 months). Analyses of 1- and 2-year follow-up data available for 3,157 (97.5%) and 2,952 (91.2%) patients, respectively, showed no significant differences in rates of stroke or systemic embolism (SE), major bleeding, and all-cause mortality for DOAC vs. warfarin users (1.2 vs. 1.8%/year, 0.5 vs. 1.2%/year, and 2.1 vs. 1.7%/year, respectively). Under propensity score matching, the incidence of stroke or SE (P=0.679) and all-cause death (P=0.864) remained equivalent, but the incidence of major bleeding was significantly lower (P=0.014) among DOAC than warfarin users. Conclusions: A high follow-up rate allowed us to obtain reliable data on the status of OAC use and therapeutic outcomes among AF patients in Japan. Warfarin and DOACs appear to yield equivalent 3-year stroke and all-cause mortality rates, but DOACs appear to reduce the risk of major bleeding.

2018-09-29 06:45:26
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1 0 0 0 OA Classification of Foliage Patterns for 3D Decorative Modeling in Digital Contents

著者: Naoya Tsuruta Sawa Hiraiwa Ryuta Motegi Kunio Kondo
出版者: Asia Digital Art and Design Association
雑誌: International Journal of Asia Digital Art and Design Association (ISSN:17388074)
巻号頁・発行日: vol.25, no.1, pp.8-13, 2021 (Released:2021-02-26)
参考文献数: 9

Demand for complicated objects in digital contents has been rising as the quality of 3D computer graphics improved. Decorative modeling is useful for enhancing the appearance of objects, however, it is also a difficult task that requires knowledge of decorative patterns. We propose a support method for 3D geometric modeling of ancient Greek and Roman style decor for use in digital contents. Our approach is based on modeling by parts synthesis. These decor styles are characterized by organic shapes of foliage and scrolls; thus, we classified 3,313 parts obtained from 200 pictures of foliage decorations mainly contains acanthus plant according to their shapes and positions. We then extracted 34 representative parts required for decorative design and constructed a 3D model library of these parts. The users can design their original decor by assembling them with existing geometric modeling tools. We found the parts can be divided broadly into two categories: fundamental parts that have curves characterize the scroll pattern and the decoration parts that decorates the curves. Efficient geometric modeling of the European style decor can be achieved by arranging fundamental parts first then decoration parts. Experimental results demonstrate that the user can significantly reduce modeling time decor using our 3D model library.

2021-09-01 22:36:59
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1 0 0 0 OA Automatic Generation of News Contents from Blog Posts

著者: Masaki Hayashi Steven Bachelder Naoya Tsuruta Takehiro Teraoka Yoshihisa Kanematsu Kazuo Sasaki Kunio Kondo
出版者: Asia Digital Art and Design Association
雑誌: International Journal of Asia Digital Art and Design Association (ISSN:17388074)
巻号頁・発行日: vol.25, no.1, pp.1-7, 2021 (Released:2021-02-26)
参考文献数: 12

To promote UGC (User Generated Content) on the Internet, several techniques have been developed to allow users to create CG animations only by writing scripts quickly. TVML (TV program Making Language) is a technology capable of obtaining TV-program-like CG animation by writing text scripts. This paper aims to propose an application that automatically converts blog posts into CG animations with news show format with the aid of TVML. The process is: 1) to fetch HTML of the blog posts and perform web scraping and natural language processing to obtain summarized speech texts, 2) to automatically give a show format received from the analysis of professional TV program to get TVML script, 3) to apply the CG character and artworks, etc. that fit the blog content to obtain the final CG animation. In this paper, we describe the process and explain the application that we developed based on the method, and explain the evaluations of the outcome produced from the blog posts.

2021-09-01 22:36:08
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1 0 0 0 OA Multiple-character Animation Systems for Children at Different Educational Stages

著者: Alaa Alherz Naoya Tsuruta Kunio Kondo
出版者: Asia Digital Art and Design Association
雑誌: International Journal of Asia Digital Art and Design Association (ISSN:17388074)
巻号頁・発行日: vol.24, no.1, pp.1-7, 2020 (Released:2020-04-10)
参考文献数: 20

Currently, children spend considerable time playing video games and watching videos, which affects their communication skills and speaking time. Previous studies have shown that visual art education helps young children to communicate their ideas. In addition, visual thinking programs improve the understanding of visual images and result in considerable improvement in mathematics, reading, and social emotional learning. In this study, we propose 2D interactive animation systems for children at different educational stages that can be used in visual art education programs. The proposed systems use a crowd simulation-based animation mechanism that does not require complicated keyframing or large amounts of hand drawings. Children have different abilities; thus, we developed two systems, one with minimum functions with voice input and the other with additional functions based on path-drawing input. The proposed systems were verified on primary school and kindergarten students. We allowed the students to use our systems freely by drawing anything and creating stories using their hand drawings. We observed that the students communicated with each other when they showed and talked about their work. The positive feedback obtained from discussion with teachers indicates that the proposed systems encourage communication between children.

2021-09-01 22:34:05
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1 0 0 0 OA Three-Year Clinical Outcomes Associated With Warfarin vs. Direct Oral Anticoagulant Use Among Japanese Patients With Atrial Fibrillation ― Findings From the SAKURA AF Registry ―

著者: Yasuo Okumura Katsuaki Yokoyama Naoya Matsumoto Eizo Tachibana Keiichiro Kuronuma Koji Oiwa Michiaki Matsumoto Toshiaki Kojima Shoji Hanada Kazumiki Nomoto Ken Arima Fumiyuki Takahashi Tomobumi Kotani Yukitoshi Ikeya Seiji Fukushima Satoru Itou Kunio Kondo Masaaki Chiku Yasumi Ohno Motoyuki Onikura Atsushi Hirayama for the SAKURA AF Registry Investigators
出版者: The Japanese Circulation Society
雑誌: Circulation Journal (ISSN:13469843)
巻号頁・発行日: pp.CJ-18-0535, (Released:2018-08-04)
参考文献数: 20
被引用文献数: 55

Background:Although direct oral anticoagulants (DOACs) are widely used in Japanese patients with atrial fibrillation (AF), large-scale investigations into their use, with suitable follow-up times and rates, are lacking.Methods and Results:The SAKURA AF Registry is a prospective multicenter registry created to investigate therapeutic outcomes of oral anticoagulant (OAC) use in Japanese AF patients. We conducted a study involving 3,237 enrollees from 63 institutions in the Tokyo area being treated with any of 4 DOACs (n=1,676) or warfarin (n=1,561) and followed-up for a median of 39.3 months (range 28.5–43.6 months). Analyses of 1- and 2-year follow-up data available for 3,157 (97.5%) and 2,952 (91.2%) patients, respectively, showed no significant differences in rates of stroke or systemic embolism (SE), major bleeding, and all-cause mortality for DOAC vs. warfarin users (1.2 vs. 1.8%/year, 0.5 vs. 1.2%/year, and 2.1 vs. 1.7%/year, respectively). Under propensity score matching, the incidence of stroke or SE (P=0.679) and all-cause death (P=0.864) remained equivalent, but the incidence of major bleeding was significantly lower (P=0.014) among DOAC than warfarin users.Conclusions:A high follow-up rate allowed us to obtain reliable data on the status of OAC use and therapeutic outcomes among AF patients in Japan. Warfarin and DOACs appear to yield equivalent 3-year stroke and all-cause mortality rates, but DOACs appear to reduce the risk of major bleeding.

2018-08-04 14:25:58
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