著者

Satoru OSHINO Naoki TANI Hui Ming KHOO Kuriko KAGITANI-SHIMONO Shin NABATAME Koji TOMINAGA Takufumi YANAGISAWA Masayuki HIRATA Haruhiko KISHIMA

出版者

The Japan Neurosurgical Society

雑誌

Neurologia medico-chirurgica (ISSN:04708105)

巻号頁・発行日

pp.2022-0300, (Released:2023-04-06)

参考文献数

11

被引用文献数

2

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Successful surgery for drug-resistant pediatric epilepsy can facilitate motor and cognitive development and improve quality of life by resolution or reduction of epileptic seizures. Therefore, surgery should be considered early in the disease course. However, in some cases, the estimated surgical outcomes are not achieved, and additional surgical treatments are considered. In this study, we investigated the clinical factors related with such unsatisfactory outcomes.We reviewed the clinical data of 92 patients who underwent 112 surgical procedures (69 resection and 53 palliation procedures). Surgical outcomes were assessed according to the postoperative disease status, which was classified as good, controlled, and poor. The following clinical factors were analyzed in relation to surgical outcome: sex, age at onset, etiology (malformation of cortical development, tumor, temporal lobe epilepsy, scar, inflammation, and non-lesional epilepsy), presence of genetic cause, and history of developmental epileptic encephalopathy. At a median of 59 (30-81.25) months after the initial surgery, the disease status was good in 38 (41%), controlled in 39 (42%), and poor in 15 (16%) patients. Among the evaluated factors, etiology exhibited the strongest correlation with surgical outcomes. Tumor-induced and temporal lobe epilepsy were correlated with good, whereas malformation of cortical development, early seizure onset, and presence of genetic cause were correlated with poor disease status. Although epilepsy surgery for the patients who present with the latter factors is challenging, these patients demonstrate a greater need for surgical treatment. Hence, development of more effective surgical options is warranted, including palliative procedures.

著者

Chiori Kamiya Kuriko Kagitani-Shimono Yoshiko Iwatani Masaya Tachibana Ikuko Mohri Masako Taniike

出版者

Japan Brain Science society

雑誌

脳科学誌 (ISSN:13415301)

巻号頁・発行日

vol.50, pp.63-100, 2021 (Released:2022-01-13)

参考文献数

60

著者

Mika Kimura Ryuzo Hanaie Ikuko Mohri Kuriko Kagitani-Shimono Masaya Tachibana Junko Matsuzaki Norihiko Fujita Yoshiyuki Watanabe Masako Taniike

出版者

Japan Brain Science society

雑誌

脳科学誌 (ISSN:13415301)

巻号頁・発行日

vol.42, pp.21-42, 2013-09-30 (Released:2017-06-01)

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Autism spectrum disorder (ASD) is a neuro-developmental disorder characterized by a number of functional abnormalities including disruptions to language. Recently, abnormal connectivity in the brain has been reported as a neuronal basis of functional impairments in ASD. Using tractographical analysis of the arcuate fasciculus (AF) by Diffusion Tensor Imaging (DTI), we attempted to clarify the neuropsychological basis for the language impairment in ASD by investigating thirteen school-aged children with ASD and eleven age- and IQ-matched control subjects. As a result of the DTI examination, no statistically significant differences in the values of fractional anisotropy (FA), axial diffusivity, radial diffusivity, and mean diffusivity were found. In both TD and ASD groups, the FA score of the AF was higher in the left hemisphere than it was in the right. We revealed that in children with ASD, the FA values of the left AF showed a positive correlation between age, verbal intelligence quotient (VIQ), and full-scale intelligence quotient (FSIQ). In addition, a negative correlation was found between RD values on the left AF with VIQ, FSIQ, and age in children with ASD. This is the first report to reveal a correlation between microconnectivity of the AF and VIQ in children diagnosed with ASD. Therefore, these findings suggest that the altered microstructural integrity of the AF may be related to verbal ability in ASD.

著者

Fumiyo Nagatani Junko Matsuzaki Moe Eto Kuriko Kagitani-Shimono Ikuko Mohri Masako Taniike

出版者

Japan Brain Science society

雑誌

脳科学誌 (ISSN:13415301)

巻号頁・発行日

vol.39, pp.5-21, 2012-10-30 (Released:2017-06-01)

参考文献数

33

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Attention deficit/hyperactivity disorder, predominantly inattentive subtype (AD/HD-I) is one of subtypes of AD/HD. Previous studies found that poor academic performance was the most common problem of children with AD/HD-I. Moreover a higher prevalence of substance dependence/abuse disorders and higher percentage experienced neurological disorders were reported in adults with this disorder. However AD/HD-I has a high risk of being overlooked due to the lack of objective measurement. To avoid these problems, it is necessary to find out children with AD/HD-I and start to intervene them early in life. AD/HD is reported to have deficits in executive function (EF), however, there have been no consistent findings regarding the presence and the characteristics of EDF in ADHD-I to date. To clarify EDF of AD/HD-I, we analyzed EF in children with AD/HD-I by using two tests designed to evaluate inhibition and working memory from CANTAB together with the BRIEF, a parent-rated scale. We found significant differences in many outcome measures of these CANTAB tests and most scales of the BRIEF between AD/HD-I and control children, indicating the presence of EDF in AD/HD-I. In addition, correlations between these tools were identified, especially in scales for working memory. We also examined predictors that distinguish AD/HD-I from controls by using discriminant analysis. In summary, outcome measures of CANTAB and the BRIEF are considered to be useful for determining AD/HD-I in young children. Short title as a running head: Assessment of executive function in children with AD/HD-I