著者

Kenji OISHI Tadashi SATO Wakae YOKOI Yasuto YOSHIDA Masahiko ITO Haruji SAWADA

出版者

(社)日本農芸化学会

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

pp.0804300864-0804300864, (Released:2008-06-07)

参考文献数

26

被引用文献数

27

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Bisphenol A (BPA), a putative endocrine disruptor, may be taken up by humans via the diet and have adverse effects on human health. In this study, we evaluated whether the probiotics, Bifidobacterium breve strain Yakult (BbY) and Lactobacillus casei strain Shirota (LcS), could exert a protective effect against dietary exposure to BPA. A group of rats fed on a diet containing 5% BbY or 5% LcS showed three advantageous effects compared to the control group; (i) the area under the blood concentration-time curve of BPA after its oral administration was significantly decreased, (ii) the amount of BPA excreted in the feces was significantly greater (2.4 times), and (iii) the percentage of BPA bound to the sediment fraction of the feces was significantly higher. These results suggest that BbY and LcS reduced the intestinal absorption by facilitating the excretion of BPA, and that these probiotics may suppress the adverse effects of BPA on human health.

著者

Kenji OISHI Tadashi SATO Wakae YOKOI Yasuto YOSHIDA Masahiko ITO Haruji SAWADA

出版者

Japan Society for Bioscience, Biotechnology, and Agrochemistry

雑誌

Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)

巻号頁・発行日

vol.72, no.6, pp.1409-1415, 2008-06-23 (Released:2008-06-23)

参考文献数

26

被引用文献数

27

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Bisphenol A (BPA), a putative endocrine disruptor, may be taken up by humans via the diet and have adverse effects on human health. In this study, we evaluated whether the probiotics, Bifidobacterium breve strain Yakult (BbY) and Lactobacillus casei strain Shirota (LcS), could exert a protective effect against dietary exposure to BPA. A group of rats fed on a diet containing 5% BbY or 5% LcS showed three advantageous effects compared to the control group; (i) the area under the blood concentration-time curve of BPA after its oral administration was significantly decreased, (ii) the amount of BPA excreted in the feces was significantly greater (2.4 times), and (iii) the percentage of BPA bound to the sediment fraction of the feces was significantly higher. These results suggest that BbY and LcS reduced the intestinal absorption by facilitating the excretion of BPA, and that these probiotics may suppress the adverse effects of BPA on human health.

著者

TADASHI KIHO MASAHIKO ITO KATSUYUKI NAGAI CHIHIRO HARA SHIGEO UKAI

出版者

The Pharmaceutical Society of Japan

雑誌

Chemical and Pharmaceutical Bulletin (ISSN:00092363)

巻号頁・発行日

vol.35, no.10, pp.4286-4293, 1987-10-25 (Released:2009-10-19)

参考文献数

34

被引用文献数

8 11

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A water-insoluble glucan (N-5P), [α] 23D +2.3° (c= 0.51, 0.5 M sodium hydroxide), was isolated from the alkaline extract of the fruit bodies of Yu er (Chinese name) (Auricularia species). N-5P was homogeneous as judged by gel filtration and electrophoresis. By gel filtration, the molecular weight of N-5P was estimated to be 5.6 × 105. The 13C-nuclear magnetic resonance and infrared spectra, together with the result of chromium trioxide oxidation, indicated that glucosidic linkages in N-5P have the β-D configuration. From the results of methylation analysis, periodate oxidation, Smith degradation (complete, as well as partial), partial acetolysis, and enzymic hydrolysis, it was concluded that N-5P has a main chain composed of β- (1→3) -linked D-glucopyranosyl residues, with single, β- (1→6) -linked D-glucopyranosyl groups attached as side chains, which account for a quarter of the total sugar residues. In addition, the results of enzymic hydrolysis indicated that the β- (1→6) -linked D-glucosyl side chains are mainly localized in the neighborhood of the nonreducing end of the main chain. Furthermore, N-5P showed potent antitumor activity against the solid form of sarcoma 180 in mice, and exhibited significant carbon clearance-enhancing activity in mice.