- 著者
- Masaya IMOTO Kazuo UMEZAWA Keiko KOMURO Tsutomu SAWA Tomio TAKEUCHI Hamao UMEZAWA
- 出版者
- The Japanese Cancer Association
- 雑誌
- Japanese Journal of Cancer Research GANN (ISSN:09105050)
- 巻号頁・発行日
- vol.78, no.4, pp.329-332, 1987 (Released:2008-03-17)
- 参考文献数
- 12
- 被引用文献数
- 3
A tyrosine protein kinase inhibitor, erbstatin, showed no antineoplastic effect on L-1210 mouse leukemia when it was injected alone. Erbstatin was found to be inactivated by incubation in serum, but not in dialyzed serum. It was also inactivated in reconstituted serum containing dialyzed serum components and ferric or ferrous ion. Because erbstatin was considered to be inactivated by the ferric or ferrous ion in serum, foroxymithine, which is a potent chelator for the ferric ion, was given to the mice together with erbstatin. Administration of both erbstatin and foroxymithine showed antineoplastic activity against L-1210 leukemia.
1 0 0 0 OA STUDIES ON A NEW EPIDERMAL GROWTH FACTOR-RECEPTOR KINASE INHIBITOR, ERBSTATIN, PRODUCED BY MH435-hF3
- 著者
- HAMAO UMEZAWA MASAYA IMOTO TSUTOMU SAWA KUNIO ISSHIKI NAOKO MATSUDA TAKESHI UCHIDA HIRONOBU IINUMA MASA HAMADA TOMIO TAKEUCHI
- 出版者
- JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- 雑誌
- The Journal of Antibiotics (ISSN:00218820)
- 巻号頁・発行日
- vol.39, no.1, pp.170-173, 1986 (Released:2006-04-19)
- 参考文献数
- 15
- 被引用文献数
- 123 159