- 著者
-
Tetsuya Tatsumi
Eishi Ashihara
Toshihide Yasui
Shinsaku Matsunaga
Atsumichi Kido
Yuji Sasada
Satoshi Nishikawa
Mitsuyoshi Hadase
Masahiro Koide
Reo Nakamura
Hidekazu Irie
Kazuki Ito
Akihiro Matsui
Hiroyuki Matsui
Maki Katamura
Shigehiro Kusuoka
Satoaki Matoba
Satoshi Okayama
Manabu Horii
Shiro Uemura
Chihiro Shimazaki
Hajime Tsuji
Yoshihiko Saito
Hiroaki Matsubara
- 出版者
- The Japanese Circulation Society
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- vol.71, no.8, pp.1199-1207, 2007 (Released:2007-07-25)
- 参考文献数
- 40
- 被引用文献数
-
59
73
Background Transplantation of non-expanded peripheral blood mononuclear cells (PBMNCs) enhances neovessel formation in ischemic myocardium and limbs by releasing angiogenic factors. This study was designed to examine whether intracoronary transplantation of PBMNCs improves cardiac function after acute myocardial infarction (AMI). Methods and Results After successful percutaneous coronary intervention (PCI) for a ST-elevation AMI with occlusion of proximal left anterior descending coronary artery within 24 h, patients were assigned to either a control group or the PBMNC group that received intracoronary infusion of PBMNCs within 5 days after PCI. PBMNCs were obtained from patients by COBE spectra-apheresis and concentrated to 10 ml, 3.3 ml of which was infused via over-the-wire catheter. The primary endpoint was the global left ventricular ejection fraction (LVEF) change from baseline to 6 months' follow-up. The data showed that the absolute increase in LVEF was 7.4% in the control group and 13.4% (p=0.037 vs control) in the PBMNC group. Cell therapy resulted in a greater tendency of ΔRegional ejection fraction (EF) or significant improvement in the wall motion score index and Tc-99m-tetrofosmin perfusion defect score associated with the infarct area, compared with controls. Moreover, intracoronary administration of PBMNCs did not exacerbate either left ventricular (LV) end-diastolic and end-systolic volume expansion or high-risk arrhythmia, without any adverse clinical events. Conclusion Intracoronary infusion of non-expanded PBMNCs promotes improvement of LV systolic function. This less invasive and more feasible approach to collecting endothelial progenitor cells may provide a novel therapeutic option for improving cardiac function after AMI. (Circ J 2007; 71: 1199 - 1207)