著者
Mari Maeda-Yamamoto Kaori Ema Manami Monobe Ikuo Shibuichi Yuki Shinoda Tomohiro Yamamoto Takao Fujisawa
出版者
一般社団法人日本アレルギー学会
雑誌
Allergology International (ISSN:13238930)
巻号頁・発行日
vol.58, no.3, pp.437-444, 2009 (Released:2009-09-11)
参考文献数
20
被引用文献数
28

Background: We previously reported that 'benifuuki' green tea containing O-methylated catechin significantly relieved the symptoms of perennial or seasonal rhinitis compared with a placebo green tea that did not contain O-methylated catechin in randomized double-blind clinical trials. In this study we assessed the effects of 'benifuuki' green tea on clinical symptoms of seasonal allergic rhinitis. Methods: An open-label, single-dose, randomized, parallel-group study was performed on 38 subjects with Japanese cedar pollinosis. The subjects were randomly assigned to long-term (December 27, 2006 - April 8, 2007, 1.5 months before pollen exposure) or short-term (February 15, 2007: after cedar pollen dispersal - April 8, 2007) drinking of a 'benifuuki' tea drink containing 34mg O-methylated catechin per day. Each subject recorded their daily symptom scores in a diary. The primary efficacy variable was the mean weekly nasal symptom medication score during the study period. Results: The nasal symptom medication score in the long-term intake group was significantly lower than that of the short-term intake group at the peak of pollen dispersal. The symptom scores for throat pain, nose-blowing, tears, and hindrance to activities of daily living were significantly better in the long-term group than the short-term group. In particular, the differences in the symptom scores for throat pain and nose-blowing between the 2 groups were marked. Conclusions: We conclude that drinking 'benifuuki' tea for 1.5 months prior to the cedar pollen season is effective in reducing symptom scores for Japanese cedar pollinosis.
著者
Manami MONOBE Kaori EMA Yoshiko TOKUDA Mari MAEDA-YAMAMOTO
出版者
Japan Society for Bioscience, Biotechnology, and Agrochemistry
雑誌
Bioscience, Biotechnology, and Biochemistry (ISSN:09168451)
巻号頁・発行日
vol.74, no.12, pp.2501-2503, 2010-12-23 (Released:2010-12-23)
参考文献数
12
被引用文献数
19

We found that the epigallocatechin gallate (EGCG)/epigallocatechin (EGC) ratio in a green tea (Camellia sinensis L.) extract was affected by the extraction temperature. The EGCG/EGC ratio in the 4 °C extract was around 1:3-4, whereas in the 100 °C extract, it was around 1:0.7. Oral administration of the mixture with a high EGC ratio (1:2-3 = EGCG/EGC) resulted in greater IgA production by murine Peyer’s patch cells.
著者
Manami MONOBE Akiko UZAWA Makiko HINO Koichi ANDO Shuji KOJIMA
出版者
Journal of Radiation Research 編集委員会
雑誌
Journal of Radiation Research (ISSN:04493060)
巻号頁・発行日
vol.46, no.1, pp.117-121, 2005 (Released:2005-04-01)
参考文献数
23
被引用文献数
21

Human whole-blood was exposed to 137Cs γ-rays or 50 keV/μm carbon ions in the presence or absence of glycine betaine, a beer component in vitro. The dicentrics of chromosome aberrations in human lymphocytes were significantly (p < 0.05) reduced by glycine betaine after irradiation with 4 Gy of either γ-rays or carbon ions. The maximum protection by glycine betaine for γ-rays or carbon ions was 37% and 20%, respectively. C3H/He female mice, aged 14 weeks, received an i.p. injection of glycine betaine 15 min before whole-body irradiation with γ-rays or 50 keV/μm carbon ions. Glycine betaine significantly (p < 0.05) increased the percent survival of irradiated mice with either γ-rays or carbon ions. In conclusion, glycine betaine is a potent protector against damages caused by low- and high-LET radiation.