著者

Yoshiyuki Yoshikawa Terutaka Hiramatsu Masaharu Sugimoto Mikiko Uemura Yuki Mori Ryoko Ichibori

出版者

The Japanese Association of Rehabilitation Medicine

雑誌

Progress in Rehabilitation Medicine (ISSN:24321354)

巻号頁・発行日

vol.7, pp.20220045, 2022 (Released:2022-09-07)

参考文献数

37

被引用文献数

2

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Objectives: This double-blind crossover-controlled trial aimed to verify the effect of electrical stimulation therapy on pressure injuries with undermining.Methods : In this trial, we compared the healing rates between a sham period and a treatment period using monophasic pulsed microcurrent therapy. The participants were randomly assigned to the sham or treatment group and received stimulation for 2 weeks. All the participants, physical therapists, and researchers were blinded to the allocation. For the main analysis, data on the effect of the intervention on changes in weekly healing and contraction rates of the wound areas, including undermining, were analyzed based on a two-period crossover study design. The intervention effect was estimated by examining the mean treatment difference for each period using Wilcoxon’s signed-rank test.Results : The reduction of the entire wound area, including the undermining area, resulted in significantly higher healing and contraction rates in the treatment group (overall wound area reduction rate: contraction rate, P=0.008; period healing rate, P=0.002).Conclusions : Electrical stimulation therapy for pressure injuries, using conditions based on the findings of an in vivo culture study, was effective in reducing the wound area.

著者

Yoshiyuki YOSHIKAWA Masaharu SUGIMOTO Noriaki MAESHIGE Mikiko UEMURA Atsushi TAKAO Kazuhiro MATSUDA Hiroto TERASHI

出版者

日本理学療法士協会

雑誌

Journal of the Japanese Physical Therapy Association (ISSN:13441272)

巻号頁・発行日

vol.17, no.1, pp.52-52, 2014 (Released:2014-12-20)

被引用文献数

1

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Purpose: The purpose of this study is to evaluate the effects of low-intensity direct current (LIDC) with electrode placement of negative poles at wound site on pressure ulcer healing. Subject: The subjects were elderly patients having a pressure ulcer (sacrum, 2 cases; thoracic supine, 2 cases; ilium, 1 case; greater trochanter, 1 case; lateral malleolus, 1 case), and healings of these ulcers had been retarded. The DESIGN-R of these ulcers were between 13 and 19. Methods: The negative electrode of silver chloride was inserted into the foam dressing on the wound surface, and the positive pole was attached on intact skin around the wound. Electrical stimulation (intensity: 80 µA; frequency: 2 Hz; pulse length: 250 msec; duration: 40 minutes) were administrated five times per week. On every treatment, opposite electrodes were shunted by electrical cable after the stimulation. Result: Size reductions were observed on all ulcers treated with LIDC and these ulcers were healed completely at 5 ~10 weeks after the beginning of LIDC stimulation. Conclusion: The pressure ulcer healings were promoted by negative LIDC stimulation. It is suggested that LIDC stimulation with consideration for electrical polarity could be effective for shortening of the pressure ulcer healing period.

著者

Mikiko UEMURA Masaharu SUGIMOTO Yoshiyuki YOSHIKAWA Terutaka HIRAMATSU Taketo INOUE

出版者

Japanese Society of Physical Therapy

雑誌

Physical Therapy Research (ISSN:21898448)

巻号頁・発行日

vol.24, no.2, pp.145-152, 2021-08-20 (Released:2021-08-20)

参考文献数

26

被引用文献数

5

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Objective: Many clinical trials have shown the therapeutic effects of electrical stimulation (ES) in various conditions. Our previous studies showed that ES (200 μA and 2 Hz) promotes migration and proliferation of human dermal fibroblasts (HDFs). However, the effective duty cycle and the effect of ES on myofibroblast differentiation are unclear. This study aimed to investigate the relationship between duty cycle and myofibroblast differentiation. Methods: HDFs were subjected to ES (200 μA and 2 Hz) for 24 h with the duty cycle adapted at 0% (control), 10%, 50%, or 90%. α-smooth muscle actin (SMA) and transforming growth factor (TGF) -β1 mRNA and α-SMA protein expressions were assessed. Collagen gel contraction was observed for 48 h after ES initiation and the gel area was measured. Cell viability and pH of culture medium were analyzed for cytotoxicity of the ES. Results: Cell viabilities were decreased in the 50% and the 90% groups but ES did not influence on pH of culture media. ES with a duty cycle of 10% significantly promoted the mRNA expression of α-SMA and TGF-β1. α-SMA protein expression in the 10% group was also significantly higher than that of the control group. Collagen gel subjected to ES with a duty cycle of 10% was contracted. Conclusion: Duty cycle can influence on myofibroblast differentiation and ES with a duty cycle 10% is the effective for wound healing.