- 著者
- Chitose Ishikawa Takayoshi Tsutamoto Masanori Fujii Hiroshi Sakai Toshinari Tanaka Minoru Horie
- 出版者
- 日本循環器学会
- 雑誌
- Circulation Journal (ISSN:13469843)
- 巻号頁・発行日
- vol.70, no.7, pp.857-863, 2006 (Released:2006-06-25)
- 参考文献数
- 31
- 被引用文献数
- 36 50
Background The prognostic role of serum C-reactive protein (CRP) in chronic heart failure (CHF) patients, especially those with nonischemic dilated cardiomyopathy (DCM), remains unknown. In the present study, whether CRP provides prognostic information in DCM patients was evaluated. Methods and Results Neurohumoral factors and hemodynamics in 84 consecutive DCM patients were measured and these patients were followed up for a mean period of 42 months. During the follow-up period, 23 patients developed cardiac events and 18 patients died of cardiac causes. Using stepwise multivariate Cox proportional hazards regression analyses, log brain natriuretic peptide (BNP) (p=0.007) and high-sensitivity CRP (hsCRP) >1 mg/L (p=0.008) were significant independent predictors of cardiac events. The patients were stratified into 4 groups based on the normal serum concentration of hsCRP (1 mg/L) and median plasma concentration of BNP (110 pg/ml). Survival rates were significantly higher in patients with hsCRP <1 mg/L and BNP <110 pg/ml. The hazard ratio of patients with BNP >110 pg/ml and hsCRP >1 mg/L was 15.8 (95% confidence interval, 1.9-127.2) compared with those with BNP <110 pg/ml and hsCRP <1 mg/L for cardiac death. Conclusions Serum hsCRP level is an independent prognostic predictor in patients with DCM and the combination of hsCRP and BNP may be useful for the management of CHF patients with DCM. (Circ J 2006; 70: 857 - 863)
- 著者
- Takuro Niidme Masanori Fujii Naotoshi Nakashima Yoshiki Katayama Yasuro Niidome
- 出版者
- (社)日本化学会
- 雑誌
- Chemistry Letters (ISSN:03667022)
- 巻号頁・発行日
- pp.150258, (Released:2015-04-17)
- 被引用文献数
- 11
Gold nanorods were intravenously injected into tumor-bearing mice. The distribution of gold in tumor tissue sections was mapped by imaging mass spectrometry (IMS) using a MALDI mass spectrometer. IMS images of tumor tissue sections indicated that the gold nanorods were not distributed throughout tumor tissues but were localized in vasculature-rich areas.
- 著者
- Masanori Fujii Naotoshi Nakashima Takuro Niidome Yasuro Niidome
- 出版者
- (社)日本化学会
- 雑誌
- Chemistry Letters (ISSN:03667022)
- 巻号頁・発行日
- vol.43, no.1, pp.131-133, 2014-01-05 (Released:2014-01-05)
- 参考文献数
- 23
- 被引用文献数
- 13
Laser-induced desorption and ionization (LDI) of gold ions (Aun+: n = 1–3) were observed from gold nanorods in a liver tissue section (thickness: 10 µm). Larger amounts of gold nanorods produced stronger mass signals. Organic molecules in the tissue were not detected and did not inhibit the LDI processes of the gold nanorods in the tissue. Because of the selective LDI processes of the gold nanorods, the distribution of gold in the liver was successfully determined by imaging mass spectrometry.