著者

Yukio Fujiwara Yoshihiro Komohara Keiichiro Tsurushima Tsuyoshi Ikeda Motohiro Takeya

出版者

日本炎症・再生医学会

雑誌

Inflammation and Regeneration (ISSN:18809693)

巻号頁・発行日

vol.30, no.6, pp.520-523, 2010 (Released:2010-12-28)

参考文献数

13

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Tumor-associated macrophages (TAMs) of M2 phenotype promote tumor proliferation and relate to poor prognosis in patients with gliobrastoma. We screened natural compounds possessing inhibitory effect on M2 polarization in human monocyte-derived macrophages. Among 130 purified natural compounds, some natural compounds such as glycyrrhizin, medicarpin and solasodine significantly inhibited the expression of CD163, one of the phenotypic markers of M2 macrophages, as well as suppressed the secretion of IL-10, one of the anti-inflammatory cytokine preferentially produced by M2 macrophages, thus suggesting that glycyrrhizin, medicarpin and solasodine suppress macrophage polarization towards M2 phenotype. Therefore, glycyrrhizin, medicarpin and solasodine may be potentially useful new strategy for the prevention and therapy of tumor.