- 著者
- Ryoji Nagai Jun-ichi Shirakawa Yukio Fujiwara Rei-ichi Ohno Narumi Moroishi Noriyuki Sakata Mime Nagai
- 出版者
- 日本酸化ストレス学会
- 雑誌
- Journal of Clinical Biochemistry and Nutrition (ISSN:09120009)
- 巻号頁・発行日
- vol.55, no.1, pp.1-6, 2014 (Released:2014-07-01)
- 参考文献数
- 29
- 被引用文献数
- 15 39
Approximately 100 years have passed since the Maillard reaction was first reported in the field of food chemistry as a condensation reaction between reducing sugars and amino acids. This reaction is thought to progress slowly primarily from glucose with proteins in vivo. An early-stage product, called the ”Amadori product”, is converted into advanced glycation end products. Those accumulate in the body in accordance with age, with such accumulation being enhanced by lifestyle-related diseases that result in the denaturation of proteins. Recent studies have demonstrated that intermediate carbonyls are generated by several pathways, and rapidly generate many glycation products. However, accurate quantification of glycation products in vivo is difficult due to instability and differences in physicochemical properties. In this connection, little is known about the relationship between the structure of glycation products and pathology. Furthermore, the interaction between proteins modified by glycation and receptors for advanced glycation end products is also known to induce the production of several inflammatory cytokines. Therefore, those inhibitors have been developed over the world to prevent lifestyle-related diseases. In this review, we describe the process of protein denaturation induced by glycation and discuss the possibility of using the process as a marker of age-related diseases.
- 著者
- Yukio Fujiwara Yoshihiro Komohara Keiichiro Tsurushima Tsuyoshi Ikeda Motohiro Takeya
- 出版者
- 日本炎症・再生医学会
- 雑誌
- Inflammation and Regeneration (ISSN:18809693)
- 巻号頁・発行日
- vol.30, no.6, pp.520-523, 2010 (Released:2010-12-28)
- 参考文献数
- 13
Tumor-associated macrophages (TAMs) of M2 phenotype promote tumor proliferation and relate to poor prognosis in patients with gliobrastoma. We screened natural compounds possessing inhibitory effect on M2 polarization in human monocyte-derived macrophages. Among 130 purified natural compounds, some natural compounds such as glycyrrhizin, medicarpin and solasodine significantly inhibited the expression of CD163, one of the phenotypic markers of M2 macrophages, as well as suppressed the secretion of IL-10, one of the anti-inflammatory cytokine preferentially produced by M2 macrophages, thus suggesting that glycyrrhizin, medicarpin and solasodine suppress macrophage polarization towards M2 phenotype. Therefore, glycyrrhizin, medicarpin and solasodine may be potentially useful new strategy for the prevention and therapy of tumor.